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Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data.

Bally M, Dendukuri N, Rich B, Nadeau L, Helin-Salmivaara A, Garbe E, Brophy JM.

BMJ. 2017 May 9;357:j1909.

A bayesian meta-analysis of individual patient data from Canadian and European healthcare databases (61460 cases of acute myocardial infarction and 385303 controls) compared non-steroidal anti-inflammatory drugs (NSAIDs) used in the general population. In the 1st week of NSAIDs use, there was a rapid increase in risk of acute myocardial infarction and there was a higher risk of myocardial infarction with higher doses of NSAIDs. With NSAID use for one to seven days, the odds ratios were 1.24 for celecoxib, 1.48 for ibuprofen, 1.50 for diclofenac, 1.53 for naproxen, and 1.58 for rofecoxib.

http://www.bmj.com/content/357/bmj.j1909

Composed by Elaine Boland.