Drug Discovery and Preclinical Drug Development – Have Animal Studies Really Failed?

  By Thomas Steckler and Malcolm Macleod  The ethics of the use of animals in research continue to be a matter for discussion, with a recent op-ed in the Journal of Translational Medicine arguing – on the grounds that non-human animals are quite different from “human animals” – that animal models can no longer be considered helpful in the development […]

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Why standardisation threatens reproducibility

BMJ Open Science encourages a number of initiatives to help the work that we publish be reproducible such as pre-submission manuscript checking, encouraging reporting guidelines, and asking authors to report the strengths and limitations of their experiments. However, reproducibility should also be considered at the study design stage. A recent study1 based on extensive preclinical data […]

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