You don't need to be signed in to read BMJ Blogs, but you can register here to receive updates about other BMJ products and services via our site.

Archive for February, 2013

MS and ALS: A common pathophysiological denominator?

6 Feb, 13 | by Steve Vucic, Web Editor

Ismail and colleagues report on a high concurrence rate of multiple sclerosis (MS) and ALS.  Interestingly, the C9orf72 expansion was identified in 80% of the ALS-MS patients.  Given that the inflammatory system appears to be deregulated in patients expressing the c9orf72 expansion, with down-regulation of the neuroprotective CXCL10 chemokine and dysfunction of NF-kB activity,   the findings in the present study imply a role for inflammation in ALS.  The implications being that modulation of these neuroinflammatory pathways may prove therapeutically useful in ALS, especially given that c0orf72 expansions may be identified in up to20% of sporadic ALS patients.

 

Ismail et al.  Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72. J Neurol Neurosurg Psychiatry 2013;84:79-87 doi:10.1136/jnnp-2012-303326.

When chocolate does not taste sweet!

6 Feb, 13 | by Steve Vucic, Web Editor

Omar and colleagues identified abnormalities in processing and identification of common flavors in patients with frontotemporal lobe syndromes.  This loss of flavor processing was associated with atrophy of the left entorhinal cortex, hippocampus, parahippocampal gyrus and temporal pole.  From a clinical perspective, these findings provide insights into abnormal eating behavior patterns in FTD and ultimately will enable a better management of such patients.

 

Omar et al.  Flavour identification in frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry J Neurol Neurosurg Psychiatry 2013;84:88-93 doi:10.1136/jnnp-2012-303853

Latest from JNNP

Latest from JNNP