Non-contiguous propagation of ALS: River of hyperexcitability?

The site of disease onset in ALS remains enigmatic, and resolution of this quandary could shed light of ALS pathogenesis and may be of therapeutic significance. Previous studies suggested a contiguous spread of disease, implying a role for local (spinal) factors in ALS pathogenesis. In contrast, Sekiguchi and colleagues report non-contiguous spread, a well observed […]

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