Wolfram syndrome type 1 is an autosomal recessive neurodegenerative disease causing many symptoms: insulin-dependent diabetes, optic neuropathy, hearing loss, diabetes insipidus, urinary disorders and balance disorders. A patient association alerted us to the possible existence of fecal incontinence in this syndrome. To confirm its existence of this symptom in this disease, we sent a questionnaire to 37 patients with Wolfram syndrome.

Seventeen patients reported fecal incontinence and constipation (45.95%). On an analog scale of 0 (mild) to 10 (very severe), this disorder is rated at 8.23.

It is important to make this symptom known so that it can be looked for and better managed. (By Dr. C. ORSSAUD, https://jmg.bmj.com/content/early/2024/12/13/jmg-2024-110233 )