Colorectal cancer tumor testing is recommended to pre-screen patients to determine who should undergo genetic testing to rule out Lynch syndrome, the most common colorectal cancer syndrome. However, compliance is low and most patients with abnormal results do not undergo Lynch syndrome screening. We developed a systems approach that was eventually automated to increase referral for genetic testing and ultimately Lynch syndrome diagnosis. As a result of the intervention, we were able to increase the proportion of patients undergoing genetic testing and doubled the percentage of patients diagnosed with Lynch syndrome with no referral differences across racial/ethnic groups. (By Dr. Xavier Llor, https://jmg.bmj.com/content/early/2022/09/17/jmg-2022-108770 )