The Canadian College of Medical Geneticists (CCMG) Laboratory Guidelines for Next-Generation Sequencing position statement provides guidance for the use of NGS in Canadian clinical genetic laboratories. The guidelines cover NGS applications for detection of variants in genomic DNA and mitochondrial DNA for inherited disorders, and for somatic variants in tumour DNA for acquired cancers. Intended users include clinical laboratories engaged in developing, validating and using NGS methods, as well as Canadian laboratory accreditation programs. The CCMG is a Canadian organization responsible for certifying medical geneticists and clinical laboratory geneticists, and for establishing professional and ethical standards for clinical genetics services in Canada. (By Dr. Tracy Stockley, https://jmg.bmj.com/content/early/2019/07/12/jmedgenet-2019-106152 )