Obesity is a global severe health problem, highly influenced by environmental factors such as a sedentary lifestyle and unhealthy eating habits. In rare cases, a genetic defect can be identified as the main cause of obesity. Our article summarizes the genetic obesity test results of 1230 Dutch obese patients. This test included 52 obesity-associated genes. A definitive diagnosis was made in nearly 4% of the patients, with the highest percentage in children (7.3%). These findings show that the diagnostic obesity gene test can be useful in a clinical setting and could help these patients to receive (future) personalized treatment. (By Dr. Lotte Kleinendorst, https://jmg.bmj.com/content/early/2018/07/03/jmedgenet-2018-105315 )