Long noncoding RNAs (lncRNAs), a class of DNA transcripts longer than 200 nucleotides with limited protein-coding potential, have been demonstradte to be crucial and pervasive cellular regulators in various physiological or pathological processes. Vision is a complex and vital perception that comprises 80% of the sensory information we receive. Based on current findings, our review represents a prospective and integrated illustration of lncRNAs’ modulation in visual maintenance and impairment. Furthermore, we also highlight challenges and future directions in conducting lncRNA studies, particularly in patients, to achieve diagnostic, prognostic and therapeutic applications. (By Dr. Yehong Zhuo, http://jmg.bmj.com/content/early/2016/12/21/jmedgenet-2016-104266 )

LncRNAs in various kinds of visual impairment. This figure displayed lncRNAs in most visual impairments mentioned in this article, including a) Blepharophimosis, ptosis and epicanthus inversus syndrome (BPES), b) Age related cataract, c) Glaucoma, d) Proliferative vitreoretinopathy (PVR), e) Uveal melanoma, f) Retinoblastoma, g) Age related macular degeneration (AMD), h) Retinal neurodegeneration, i) Retinopathy of prematurity (ROP), j) Diabetic retinopathy (DR).