A well-designed and rigorous genome-wide association study (GWAS) on tuberculosis (TB) susceptibility provided an opportunity to examine the genetic association from previously reported TB candidate genes. We performed a simulation study based on the Wellcome Trust Case-Control Consortium (WTCCC) TB GWAS data. As shown by our simulation results, the previously reported TB candidate genes were not supported by the GWAS data. (By Dr. Hui-Qi Qu, http://jmg.bmj.com/content/early/2011/01/10/jmg.2010.087361?papetoc= )