Failed PrEP trial (VOICE) participants give reasons for their poor adherence

Despite indications of the acceptability of Pre-Exposure Prophylaxis (PrEP) among certain populations (MSM in London (STI/Aghaizu & Nardone) 2013, and Australia (STI/Holt & De Wit) 2012), the extremely varied results that have emanated from large studies seeking to determine its efficacy and effectiveness as a preventative intervention remain a concern.  To name the most important […]

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The dapivirine ring: success at last for a vaginal microbicide?

The International Partnership for Microbicides (IPM) has just announced the launch of a trial (IPM 027) to evaluate the effectiveness of the antiretroviral (ARV) drug dapivirine delivered by means of a monthly replaceable vaginal ring (http://www.ipmglobal.org/node/670).  The IPM study, which has enrolled 1,650 women at four sites in South Africa, is part of a broader […]

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Putting Rectal Microbicides “On the Map”

17th April saw the launch of the report: On the Map: Assuring Africa’s Place in Rectal Microbicide Research and Advocacy by the International Rectal Microbicide Advocates (IRMA) On the Map:  Ensuring Africa’s Place in Rectal Microbicide Research and Advocacy .  The report has been developed by African advocates and researchers on the basis of an […]

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A biomarker for the efficacy of new antiretroviral microbicides?

A recent study claims to have proved the correlation between HIV-1 RNA in the genital secretions of infected individuals and HIV transmission (Spearman’s rank correlation coefficient ρ was 0.56 for endocervical samples, and 0.55 for semen).  Mechanisms of transmission of HIV transmission through genital mucosa are still not well understood.  But, prior to this study, […]

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