{"id":696,"date":"2012-07-11T09:26:31","date_gmt":"2012-07-11T09:26:31","guid":{"rendered":"https:\/\/blogs.bmj.com\/sti\/?p=696"},"modified":"2012-07-10T20:27:41","modified_gmt":"2012-07-10T20:27:41","slug":"the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/","title":{"rendered":"The dapivirine ring: success at last for a vaginal microbicide?"},"content":{"rendered":"<p>The International Partnership for Microbicides (IPM) has just announced the launch of a trial (IPM 027) to evaluate the effectiveness of the antiretroviral (ARV) drug dapivirine delivered by means of a monthly replaceable vaginal ring (<a href=\"http:\/\/www.ipmglobal.org\/node\/670\">http:\/\/www.ipmglobal.org\/node\/670<\/a>).\u00a0 The IPM study, which has enrolled 1,650 women at four sites in South Africa, is part of a broader licensing program which also includes the Microbicides Trial Network (MTN) study ASPIRE (MTN-020) due to commence in the coming months (<a href=\"http:\/\/www.mtnstopshiv.org\/studies\/3614\">http:\/\/www.mtnstopshiv.org\/studies\/3614<\/a>).<\/p>\n<p>The development of an effective vaginal microbicide would be a significant new weapon in the armoury of HIV prevention \u2013 not least because, for the first time, it would place a means of protection in the hands of women, who are often most at risk from the virus. \u00a0On the down side, there is the probable impact on condom use. \u00a0The potential contribution of microbicides has been the object of various modelling studies:\u00a0 Foss &amp; Watts (2009) predict a significant impact in contexts of low and high HIV prevalence with microbicides of even moderate efficacy (<a href=\"http:\/\/sti.bmj.com\/content\/85\/4\/276.abstract?sid=ec0fb4c2-06ee-4358-a8af-6e06c015bf05\">http:\/\/sti.bmj.com\/content\/85\/4\/276.abstract?sid=ec0fb4c2-06ee-4358-a8af-6e06c015bf05<\/a>): while Cox and White ( 2011) argue that reductions of 30% in fifteen years could be achieved, if 49% levels of microbicide use were combined with 67% levels of male circumcision (<a href=\"http:\/\/sti.bmj.com\/content\/87\/7\/635.abstract?sid=ec0fb4c2-06ee-4358-a8af-6e06c015bf05\">http:\/\/sti.bmj.com\/content\/87\/7\/635.abstract?sid=ec0fb4c2-06ee-4358-a8af-6e06c015bf05<\/a>). \u00a0As for cost-effectiveness, Verguet &amp; Watts give positive results for high-prevalence contexts (&gt;2.4%) even with a low efficacy microbicide (<a href=\"http:\/\/sti.bmj.com\/content\/86\/3\/212.abstract?sid=ec0fb4c2-06ee-4358-a8af-6e06c015bf05\">http:\/\/sti.bmj.com\/content\/86\/3\/212.abstract?sid=ec0fb4c2-06ee-4358-a8af-6e06c015bf05<\/a>).<\/p>\n<p>So far, unfortunately, the microbicides have not come up with the goods.\u00a0 Some 23 products are currently in the course of development.\u00a0 Microbicides act in different ways \u2013 some by creating a physical barrier, such as PRO2000, a trial of which is discussed by Kamali &amp; Lacey (2009) (<a href=\"http:\/\/sti.bmj.com\/content\/86\/3\/222.abstract?sid=ec0fb4c2-06ee-4358-a8af-6e06c015bf05\">http:\/\/sti.bmj.com\/content\/86\/3\/222.abstract?sid=ec0fb4c2-06ee-4358-a8af-6e06c015bf05<\/a>): others by enhancing vaginal defence mechanisms or by disabling the pathogens. \u00a0Trials of these microbicides having proved unsuccessful, the most promising candidates now seem to be ARV drugs which prevent replication of the virus inside the cell. Amongst the latter are Tenofovir gel, unsuccessfully trialled by the MTN VOICE trial (MTN 003), and now, most recently, the dapivirine ring, soon to be tested by IPM 027 and MTN ASPIRE (<a href=\"http:\/\/www.mtnstopshiv.org\/node\/82\">http:\/\/www.mtnstopshiv.org\/node\/82<\/a>).<\/p>\n<p>Both of the trials recently announced (IPM 027 and MTN 020) are phase III trials at the cutting edge of microbicide research.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The International Partnership for Microbicides (IPM) has just announced the launch of a trial (IPM 027) to evaluate the effectiveness of the antiretroviral (ARV) drug dapivirine delivered by means of a monthly replaceable vaginal ring (http:\/\/www.ipmglobal.org\/node\/670).\u00a0 The IPM study, which has enrolled 1,650 women at four sites in South Africa, is part of a broader [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":152,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[264,2012,2257],"tags":[],"class_list":["post-696","post","type-post","status-publish","format-standard","hentry","category-health-policy","category-hiv-infection","category-microbicides"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The dapivirine ring: success at last for a vaginal microbicide?  - Sexually Transmitted Infections<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The dapivirine ring: success at last for a vaginal microbicide?  - Sexually Transmitted Infections\" \/>\n<meta property=\"og:description\" content=\"The International Partnership for Microbicides (IPM) has just announced the launch of a trial (IPM 027) to evaluate the effectiveness of the antiretroviral (ARV) drug dapivirine delivered by means of a monthly replaceable vaginal ring (http:\/\/www.ipmglobal.org\/node\/670).\u00a0 The IPM study, which has enrolled 1,650 women at four sites in South Africa, is part of a broader [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/\" \/>\n<meta property=\"og:site_name\" content=\"Sexually Transmitted Infections\" \/>\n<meta property=\"article:published_time\" content=\"2012-07-11T09:26:31+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"The dapivirine ring: success at last for a vaginal microbicide?\",\"datePublished\":\"2012-07-11T09:26:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/\"},\"wordCount\":436,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#organization\"},\"articleSection\":[\"health policy\",\"HIV infection\",\"microbicides\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/\",\"name\":\"The dapivirine ring: success at last for a vaginal microbicide? - Sexually Transmitted Infections\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#website\"},\"datePublished\":\"2012-07-11T09:26:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2012\\\/07\\\/11\\\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The dapivirine ring: success at last for a vaginal microbicide?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/\",\"name\":\"Sexually Transmitted Infections\",\"description\":\"Discussion and suggestion space for readers of STIs\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#organization\",\"name\":\"Sexually Transmitted Infections\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/files\\\/2017\\\/10\\\/blog-logo-sti.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/files\\\/2017\\\/10\\\/blog-logo-sti.png\",\"width\":378,\"height\":34,\"caption\":\"Sexually Transmitted Infections\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/author\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The dapivirine ring: success at last for a vaginal microbicide?  - Sexually Transmitted Infections","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/","og_locale":"en_US","og_type":"article","og_title":"The dapivirine ring: success at last for a vaginal microbicide?  - Sexually Transmitted Infections","og_description":"The International Partnership for Microbicides (IPM) has just announced the launch of a trial (IPM 027) to evaluate the effectiveness of the antiretroviral (ARV) drug dapivirine delivered by means of a monthly replaceable vaginal ring (http:\/\/www.ipmglobal.org\/node\/670).\u00a0 The IPM study, which has enrolled 1,650 women at four sites in South Africa, is part of a broader [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/","og_site_name":"Sexually Transmitted Infections","article_published_time":"2012-07-11T09:26:31+00:00","twitter_card":"summary_large_image","twitter_misc":{"Written by":"","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/"},"author":{"name":"","@id":""},"headline":"The dapivirine ring: success at last for a vaginal microbicide?","datePublished":"2012-07-11T09:26:31+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/"},"wordCount":436,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/sti\/#organization"},"articleSection":["health policy","HIV infection","microbicides"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/","url":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/","name":"The dapivirine ring: success at last for a vaginal microbicide? - Sexually Transmitted Infections","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/sti\/#website"},"datePublished":"2012-07-11T09:26:31+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/sti\/2012\/07\/11\/the-dapivirine-ring-success-at-last-for-a-vaginal-microbicide\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/sti\/"},{"@type":"ListItem","position":2,"name":"The dapivirine ring: success at last for a vaginal microbicide?"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/sti\/#website","url":"https:\/\/blogs.bmj.com\/sti\/","name":"Sexually Transmitted Infections","description":"Discussion and suggestion space for readers of STIs","publisher":{"@id":"https:\/\/blogs.bmj.com\/sti\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/sti\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/sti\/#organization","name":"Sexually Transmitted Infections","url":"https:\/\/blogs.bmj.com\/sti\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/sti\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/sti\/files\/2017\/10\/blog-logo-sti.png","contentUrl":"https:\/\/blogs.bmj.com\/sti\/files\/2017\/10\/blog-logo-sti.png","width":378,"height":34,"caption":"Sexually Transmitted Infections"},"image":{"@id":"https:\/\/blogs.bmj.com\/sti\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"","url":"https:\/\/blogs.bmj.com\/sti\/author\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/posts\/696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/users\/152"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/comments?post=696"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/posts\/696\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/media?parent=696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/categories?post=696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/tags?post=696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}