{"id":1514,"date":"2022-07-06T10:25:55","date_gmt":"2022-07-06T09:25:55","guid":{"rendered":"https:\/\/blogs.bmj.com\/sti\/?p=1514"},"modified":"2022-07-06T10:25:55","modified_gmt":"2022-07-06T09:25:55","slug":"ichr-2022","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/sti\/2022\/07\/06\/ichr-2022\/","title":{"rendered":"International Conference on Human Retrovirology: HTLV 2022"},"content":{"rendered":"<h3><strong>International Conference on Human Retrovirology: HTLV 2022<\/strong><\/h3>\n<p>On World HTLV Day (10 November 2021) we recorded a podcast on the patient, clinician and scientist\u2019s perspective of Human T Leukaemia Virus-1 (HTLV-1). Today we present you an update on the latest International Retrovirology Conference: HTLV 22 held in Melbourne, Australia.<\/p>\n<p>HTLV-1 is a sexually and vertically transmitted virus that is distantly related to HIV and capable of causing severe, chronic and progressive diseases such as adult T cell leukaemia, HTLV-1 associated myelopathy (HAM\/TSP) and bronchiectasis. The natural history of HTLV-1 is mostly asymptomatic and the majority of those who carry the virus remain undiagnosed. The mostly silent nature of the virus, compounded <span style=\"font-size: 1rem\">by a lack of public health response (e,g, of STI and antenatal care screening programmes) has led to <\/span><span style=\"font-size: 1rem\">unchecked transmission. Forty years after its discovery HTLV-1 remains a neglected human pathogen, with no specific anti-retroviral treatment or vaccine available.<\/span><\/p>\n<p>The future of HTLV-1 therapeutics and recognition by national and international public health organisations is promising as discussed in this <a href=\"https:\/\/soundcloud.com\/bmjpodcasts\/htlv2022-20th-international-conference-on-human-retrovirology?in=bmjpodcasts\/sets\/sti\">special episode of STI podcast<\/a> dedicated to the 2022 International Conference on Human Retrovirology. Join Dr Fabiola Martin and her guests the Australian HTLV-1 patient representative, Ms Joanna Curteis, Dr Carolina Rosadas, HTLV-1 scientist at Imperial College London, UK and Prof Damian Purcell, HTLV-1 at Doherty Institute, Melbourne, Australia.<\/p>\n<p><strong>Highlights<\/strong><\/p>\n<p><strong>HTLV-1 Epidemiology<\/strong><\/p>\n<ul>\n<li>Internationally antenatal care screening (ANC) for HTLV-1 is not routinely adopted, though there is compelling evidence from Japan and Martinique that ANC screening does reduce HTLV-1 prevalence. Prates et al reported that in Brazil a cohort of 292 HTLV-1 positive mothers followed over 24 years, the vertical transmission rate was 15%, with prolonged breastfeeding being the most significant risk factor. <a href=\"https:\/\/az659834.vo.msecnd.net\/eventsairaueprod\/production-ashm-public\/226399f0022c467a97914027f01eefca\"><em>Determinants for the HTLV-1 maternal-to-child Transmission.<\/em><\/a><\/li>\n<li>HTLV-1 is primarily sexually transmitted. A recent study measured the HTLV-1 proviral load in two discrete sites, vaginal fluid and peripheral blood mononuclear cells (PBMCs) among 57 women diagnosed with HTLV-1. The mean HTLV-1 pro-viral load was higher in PBMCs than vaginal fluid and there was a strong direct correlation between the mean pro-viral load of PBMCs with vaginal fluid. <a href=\"https:\/\/az659834.vo.msecnd.net\/eventsairaueprod\/production-ashm-public\/535799d3ecc04d478c195b3ee9ba9c95\"><em>HTLV-1 proviral load in vaginal fluid correlates directly with proviral load in peripheral blood mononuclear cells of infected women.<\/em><\/a><\/li>\n<\/ul>\n<p><strong>PrEP for HTLV-1<\/strong><\/p>\n<ul>\n<li>Pre-exposure prophylaxis for HTLV-1 is feasible. Animal model studies have shown that the integrase strand transfer inhibitor (INSTI) carbotegravir prevents the transmission of HTLV-1. Cabotegravir is a long-acting injectable antiretroviral already approved for the treatment of HIV-1. Given the extended half-life of cabotegravir, these findings highlight the potential of the first PrEP agent for HTLV. <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.889621\/full\"><em>Cabotegravir, the long-acting integrase strand transfer inhibitor, potently inhibits human T-cell lymphotropic virus type 1 transmission in vitro.<\/em><\/a><\/li>\n<li>Combination administration of tenofovir alafenamide and dolutegravir (TAF+DTG) anti-retroviral therapy in animal models achieved high intracellular concentrations and was effective at preventing <em>de novo<\/em> infection within the humanised animal model. These data provide support for the evaluation of TAF+DTG as HTLV-1 PrEP in human studies. <a href=\"https:\/\/az659834.vo.msecnd.net\/eventsairaueprod\/production-ashm-public\/d720d01fff4849829901bd956c4ac8be\"><em>Combination antiretroviral therapy and MCL1 inhibition mitigate HTLV-1 infection in vivo.<\/em><\/a><\/li>\n<\/ul>\n<p><strong>HTLV-1 Advocacy<\/strong><\/p>\n<ul>\n<li>The International Retrovirology Association (IRVA) released an open letter calling for a Global Action to eliminate HTLV-1: Rapid implementation of HTLV-1 prevention strategies and effective linkage with care and research funding is requested: 371 individuals and 36 organisations so far have endorsed this letter and further signatures will be collected on the new IRVA website.<\/li>\n<li>Dr Meg Doherty presented the WHO HTLV-1 position papers and recommendations about the mapping, prevention and elimination of HTLV-1.<\/li>\n<\/ul>\n<ul>\n<li>At the opening ceremony, a message from Director General Dr Thedros Adhanom Ghebreyes informed the HTLV-1 community that at the 2022 World Health Assembly WHO will ask member states to endorse HTLV-1 as an STI. This will be a huge breakthrough in making HTLV-1 visible.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1515\" src=\"https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm.png\" alt=\"\" width=\"3022\" height=\"1714\" srcset=\"https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm.png 3022w, https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm-300x170.png 300w, https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm-1024x581.png 1024w, https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm-768x436.png 768w, https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm-1536x871.png 1536w, https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm-2048x1162.png 2048w, https:\/\/blogs.bmj.com\/sti\/files\/2022\/07\/Screen-Shot-2022-05-13-at-4.50.49-pm-640x363.png 640w\" sizes=\"auto, (max-width: 3022px) 100vw, 3022px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Additional Resources<\/p>\n<p>Advocacy and patient information<\/p>\n<p><a href=\"http:\/\/www.htlvnet.com\/\">http:\/\/www.htlvnet.com\/<\/a><\/p>\n<p><a href=\"http:\/\/www.htlvaware.com\/\">http:\/\/www.htlvaware.com\/<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/channel\/UCI6aLSTtk7chXMeybJ92Fhw\">https:\/\/www.youtube.com\/channel\/UCI6aLSTtk7chXMeybJ92Fhw<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>National Centre for Human Retrovirology<\/p>\n<p><a href=\"http:\/\/www.htlv.eu\/\">http:\/\/www.htlv.eu\/<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>WHO HTLV Technical Report<\/p>\n<p><a href=\"https:\/\/apps.who.int\/iris\/handle\/10665\/339773\">https:\/\/apps.who.int\/iris\/handle\/10665\/339773<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.881547\/full\">HTLV-1 Transmission and HIV Pre-exposure Prophylaxis: A Scoping Review<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.844265\/full\">Prevalence and Risk Factors for Human T-Cell Lymphotropic Virus (HTLV) in Blood Donors in Brazil\u2014A 10-Year Study (2007\u20132016)<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/az659834.vo.msecnd.net\/eventsairaueprod\/production-ashm-public\/29b4c5f9cd684671902deff84cbaed57\">Recent advances in HTLV-1 epidemiology.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.859115\/full\">Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of the Implementation of Public Health Policies on HTLV-1 in Brazil<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8370991\/\">Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>International Conference on Human Retrovirology: HTLV 2022 On World HTLV Day (10 November 2021) we recorded a podcast on the patient, clinician and scientist\u2019s perspective of Human T Leukaemia Virus-1 (HTLV-1). Today we present you an update on the latest International Retrovirology Conference: HTLV 22 held in Melbourne, Australia. HTLV-1 is a sexually and vertically [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/sti\/2022\/07\/06\/ichr-2022\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":377,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1514","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>International Conference on Human Retrovirology: HTLV 2022 - Sexually Transmitted Infections<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/sti\/2022\/07\/06\/ichr-2022\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"International Conference on Human Retrovirology: HTLV 2022 - Sexually Transmitted Infections\" \/>\n<meta property=\"og:description\" content=\"International Conference on Human Retrovirology: HTLV 2022 On World HTLV Day (10 November 2021) we recorded a podcast on the patient, clinician and scientist\u2019s perspective of Human T Leukaemia Virus-1 (HTLV-1). 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Today we present you an update on the latest International Retrovirology Conference: HTLV 22 held in Melbourne, Australia. 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