{"id":1046,"date":"2014-11-17T15:09:28","date_gmt":"2014-11-17T15:09:28","guid":{"rendered":"https:\/\/blogs.bmj.com\/sti\/?p=1046"},"modified":"2014-11-12T11:11:29","modified_gmt":"2014-11-12T11:11:29","slug":"tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/","title":{"rendered":"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis"},"content":{"rendered":"

\u201cDistribution of HIV-1 subtypes in a population\u201d, state Mumtaz & Raddad (STI)<\/a> in a study of the HIV pandemic in the Middle East, \u201ctracks the spread and evolution of the epidemic\u201d. \u00a0Various studies covered in our previous blogs have attempted to read the history of the progress of the HIV epidemic through the evidence of the distribution of HIV genetic sub-types: Tatem & Salemi (STI\/blogs)<\/a> have investigated its spread throughout Africa; Zhao & Roca (STI\/blogs)<\/a> pass beyond the human epidemic to consider the genetic evidence for repeated transmission from chimpanzees to humans.<\/p>\n

Now Faria & Lemey<\/a> (F&L), in a paper recently appearing in Science<\/em>, offer an account of the critical early phase of limited spread within Central Africa and the ignition of pandemic HIV-1 around 1960, bringing statistical approaches to bear to HIV-1 sequence data. \u00a0F&L produce a time-scaled phylogenetic \u201ctree\u201d of HIV-1 group M lineages, matching these up in each case with the geographical location of their earliest manifestation.<\/p>\n

This approach points to the very strong likelihood (PP = 0.99) of an origin of the HIV1 epidemic in Kinshasa around 1920. Study of lineage migration shows comparatively early spread from Kinshasa to Brazzaville (Republic of Congo (RC)), and Mbuji-Mayi and Lubumbashi (southern Democratic Republic of Congo (DRC)) along the railway network, and its arrival around a decade later in Bwamanda and Kisangani (northern DRC).\u00a0 The crucial period around 1960 (1952-1968) sees, for group M HIV-1, an exponential growth in levels of M-group transmission, while growth in group O transmission remains at previous levels.<\/p>\n

But the most interesting aspect of the study relates to conditions around the sudden surge in group M HIV-1 transmission, as indicated by the accelerated ramification of viral lineages during the crucial period.\u00a0 The authors consider the hypothesis that associates this ramification with the geographic dispersal of the epidemic, with the lineages emerging in the more widely distributed populations now being infected.\u00a0 They reject this hypothesis, however, on the grounds that, when the epidemic history of lineages maintaining ancestry within Kinshasa is constructed, these turn out to exhibit phylo-genetic characteristics that are comparable to those of lineages in central Africa.<\/p>\n

They conclude that the crucial explosion of pandemic HIV-1 transmission probably occurred in Kinshasa as a result of a historic contingency affecting a particular population subgroup.\u00a0 Prime contenders are iatrogenic transmission as a result of the administration of unsterilized injections at STI clinics, and\/or post-independence changes in sexual behaviour e.g. among commercial sex-workers.\u00a0 The authors find support for the iatrogenic hypothesis in a study of the hepatitis C virus in the DRC which shows that it exhibits an age cohort effect, and in reports of an epidemic of hepatitis B in Kinshasa around 1951-2.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u201cDistribution of HIV-1 subtypes in a population\u201d, state Mumtaz & Raddad (STI) in a study of the HIV pandemic in the Middle East, \u201ctracks the spread and evolution of the epidemic\u201d. \u00a0Various studies covered in our previous blogs have attempted to read the history of the progress of the HIV epidemic through the evidence of […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":152,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[151,2783,2274,2252],"tags":[],"class_list":["post-1046","post","type-post","status-publish","format-standard","hentry","category-epidemiology","category-historical","category-hiv-epidemiology","category-medical-history"],"yoast_head":"\nTracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis - Sexually Transmitted Infections<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis - Sexually Transmitted Infections\" \/>\n<meta property=\"og:description\" content=\"\u201cDistribution of HIV-1 subtypes in a population\u201d, state Mumtaz & Raddad (STI) in a study of the HIV pandemic in the Middle East, \u201ctracks the spread and evolution of the epidemic\u201d. \u00a0Various studies covered in our previous blogs have attempted to read the history of the progress of the HIV epidemic through the evidence of [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/\" \/>\n<meta property=\"og:site_name\" content=\"Sexually Transmitted Infections\" \/>\n<meta property=\"article:published_time\" content=\"2014-11-17T15:09:28+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2014\\\/11\\\/17\\\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2014\\\/11\\\/17\\\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\\\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis\",\"datePublished\":\"2014-11-17T15:09:28+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2014\\\/11\\\/17\\\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\\\/\"},\"wordCount\":467,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#organization\"},\"articleSection\":[\"Epidemiology\",\"Historical\",\"HIV Epidemiology\",\"Medical history\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2014\\\/11\\\/17\\\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2014\\\/11\\\/17\\\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\\\/\",\"name\":\"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis - Sexually Transmitted Infections\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#website\"},\"datePublished\":\"2014-11-17T15:09:28+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2014\\\/11\\\/17\\\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2014\\\/11\\\/17\\\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/2014\\\/11\\\/17\\\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/\",\"name\":\"Sexually Transmitted Infections\",\"description\":\"Discussion and suggestion space for readers of STIs\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#organization\",\"name\":\"Sexually Transmitted Infections\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/files\\\/2017\\\/10\\\/blog-logo-sti.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/files\\\/2017\\\/10\\\/blog-logo-sti.png\",\"width\":378,\"height\":34,\"caption\":\"Sexually Transmitted Infections\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/sti\\\/author\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis - Sexually Transmitted Infections","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/","og_locale":"en_US","og_type":"article","og_title":"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis - Sexually Transmitted Infections","og_description":"\u201cDistribution of HIV-1 subtypes in a population\u201d, state Mumtaz & Raddad (STI) in a study of the HIV pandemic in the Middle East, \u201ctracks the spread and evolution of the epidemic\u201d. \u00a0Various studies covered in our previous blogs have attempted to read the history of the progress of the HIV epidemic through the evidence of [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/","og_site_name":"Sexually Transmitted Infections","article_published_time":"2014-11-17T15:09:28+00:00","twitter_card":"summary_large_image","twitter_misc":{"Written by":"","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/"},"author":{"name":"","@id":""},"headline":"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis","datePublished":"2014-11-17T15:09:28+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/"},"wordCount":467,"publisher":{"@id":"https:\/\/blogs.bmj.com\/sti\/#organization"},"articleSection":["Epidemiology","Historical","HIV Epidemiology","Medical history"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/","url":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/","name":"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis - Sexually Transmitted Infections","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/sti\/#website"},"datePublished":"2014-11-17T15:09:28+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/sti\/2014\/11\/17\/tracking-the-origin-early-spread-and-ignition-of-pandemic-hiv-1-through-new-approaches-to-phylogenetic-analysis\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/sti\/"},{"@type":"ListItem","position":2,"name":"Tracking the origin, early spread, and ignition of pandemic #HIV-1 through new approaches to phylogenetic analysis"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/sti\/#website","url":"https:\/\/blogs.bmj.com\/sti\/","name":"Sexually Transmitted Infections","description":"Discussion and suggestion space for readers of STIs","publisher":{"@id":"https:\/\/blogs.bmj.com\/sti\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/sti\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/sti\/#organization","name":"Sexually Transmitted Infections","url":"https:\/\/blogs.bmj.com\/sti\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/sti\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/sti\/files\/2017\/10\/blog-logo-sti.png","contentUrl":"https:\/\/blogs.bmj.com\/sti\/files\/2017\/10\/blog-logo-sti.png","width":378,"height":34,"caption":"Sexually Transmitted Infections"},"image":{"@id":"https:\/\/blogs.bmj.com\/sti\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"","url":"https:\/\/blogs.bmj.com\/sti\/author\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/posts\/1046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/users\/152"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/comments?post=1046"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/posts\/1046\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/media?parent=1046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/categories?post=1046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/sti\/wp-json\/wp\/v2\/tags?post=1046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}