{"id":1393,"date":"2019-04-17T14:44:00","date_gmt":"2019-04-17T14:44:00","guid":{"rendered":"https:\/\/blogs.bmj.com\/spcare\/?p=1393"},"modified":"2019-04-17T14:44:00","modified_gmt":"2019-04-17T14:44:00","slug":"news-and-updates-from-www-palliativedrugs-com-106","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/spcare\/2019\/04\/17\/news-and-updates-from-www-palliativedrugs-com-106\/","title":{"rendered":"News and updates from www.palliativedrugs.com"},"content":{"rendered":"<p><em><strong>Selected items from the News and Latest Additions sections of <a href=\"http:\/\/www.palliativedrugs.com\">www.palliativedrugs.com<\/a>, the world\u2019s leading palliative care website with over 30,000 members from 169 Countries.<\/strong><\/em><\/p>\n<h3>SAFETY UPDATES<\/h3>\n<p><b>CME T34 syringe pumps now require foam pads to be added to the battery compartment<\/b><\/p>\n<p><span style=\"font-weight: 400\">All Caesarea Medical Electronics (CME) T34 Ambulatory syringe pumps in the UK now need a foam pad to be added to the battery compartment to ensure the battery rests securely against the contacts. Kits should be ordered from CME to do this.<\/span><\/p>\n<p><span style=\"font-weight: 400\">This information is in the latest CME field safety notice (FSN2018-001_Updated) and follows the previous alerts in <\/span><a href=\"https:\/\/www.palliativedrugs.com\/news\/april\/t34-syringe-pumps-mhra-alert.html\"><span style=\"font-weight: 400\">March<\/span><\/a><span style=\"font-weight: 400\"> and <\/span><a href=\"https:\/\/www.palliativedrugs.com\/news\/september\/t34-syringe-pumps-updated-safety-warning.html\"><span style=\"font-weight: 400\">September<\/span><\/a><span style=\"font-weight: 400\"> 2018, highlighting the possible loss of function due to inadequate battery connection. For more information, click <\/span><a href=\"https:\/\/www.palliativedrugs.com\/download\/CME%20McKinley%20-%20January%202019.pdf\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>Risk of severe and fatal burns with emollients<\/b><\/p>\n<p><span style=\"font-weight: 400\">Warnings about the risk of severe and fatal burns are being extended to all paraffin-based emollients regardless of the paraffin concentration. The Medicines and Healthcare products Regulatory Agency (MHRA) state that the emollients themselves are not flammable, however they act as an accelerant when there is a build-up of emollient on fabric, e.g. clothing, bedding or dressings. Patients should be instructed not to smoke or go near naked flames. For more information, click <\/span><a href=\"https:\/\/www.gov.uk\/drug-safety-update\/emollients-new-information-about-risk-of-severe-and-fatal-burns-with-paraffin-containing-and-paraffin-free-emollients\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>MHRA new restrictions and precautions for fluoroquinolone antibiotics<\/b><\/p>\n<p><span style=\"font-weight: 400\">New restrictions and precautions for use of fluoroquinolone antibiotics (ciprofloxacin, levofloxacin, moxifloxacin and ofloxacin) are being introduced by the MHRA following very rare reports of potentially irreversible undesirable effects affecting the musculoskeletal and nervous systems, e.g. tendinitis, muscle pain, joint pain, peripheral neuropathy. Information for health professionals includes:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">to advise patients to stop treatment at the first signs of a serious undesirable effect and to contact their doctor immediately for further advice<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">not to prescribe fluoroquinolones:<\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">for non-severe or self-limiting infections, or non-bacterial conditions<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">for some mild\u2013moderate infections unless other antibiotics that are commonly recommended are considered inappropriate (see <\/span><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/referral\/quinolone-fluoroquinolone-article-31-referral-annex-iii_en.pdf\"><span style=\"font-weight: 400\">updated SPC indications<\/span><\/a><span style=\"font-weight: 400\">)<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">to prescribe with special caution for people at a higher risk of tendon injury, e.g. &gt;60 years, those with renal impairment or solid-organ transplants<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">to avoid use of a corticosteroid with a fluoroquinolone as this may increase the risk of tendinitis and tendon rupture<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">to report suspected undesirable effects via the MHRA yellow card scheme.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">Full details are available in the MHRA March 2019 Drug Safety Update. An <\/span><a href=\"https:\/\/assets.publishing.service.gov.uk\/media\/5c9364c6e5274a48edb9a9fa\/FQ-patient-sheet-final.pdf\"><span style=\"font-weight: 400\">advice sheet<\/span><\/a><span style=\"font-weight: 400\"> for patients has also been produced. For more information, click <\/span><a href=\"https:\/\/www.gov.uk\/drug-safety-update\/fluoroquinolone-antibiotics-new-restrictions-and-precautions-for-use-due-to-very-rare-reports-of-disabling-and-potentially-long-lasting-or-irreversible-side-effects\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3>HOT TOPICS<\/h3>\n<p><b>Cochrane review: Pregabalin for neuropathic pain<\/b><\/p>\n<p><span style=\"font-weight: 400\">An update on the use of pregabalin for neuropathic pain in adults, has found no substantial change from the 2009 findings. There is evidence of efficacy in postherpetic neuralgia, painful diabetic neuropathy, and mixed or unclassified post-traumatic neuropathic pain; there a lack of efficacy in HIV neuropathy and inadequate evidence of efficacy in central neuropathic pain. Some people will derive substantial benefit with pregabalin; more will have moderate benefit, but many will have no benefit or will discontinue treatment. For more information, click <\/span><a href=\"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD007076.pub3\/full\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>Pharmacies now able to dispense controlled drugs via the Electronic Prescription Service<\/b><\/p>\n<p><span style=\"font-weight: 400\">NHS Digital is rolling out prescribing Schedule 2 and 3 controlled drugs, except oral liquid methadone, via the Electronic Prescription Service, following a successful trial in GP practices. For more information, click <\/span><a href=\"https:\/\/digital.nhs.uk\/news-and-events\/latest-news\/pharmacies-now-able-to-dispense-controlled-drugs-via-electronic-prescription-service\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>Gosport report: Pharmacy bodies publish a reflection and learning resource <\/b><\/p>\n<p><span style=\"font-weight: 400\">The General Pharmaceutical Council, Royal Pharmaceutical Society and Association of Pharmacy Technicians in the UK have joined together to publish a reflection and learning <\/span><a href=\"https:\/\/www.rpharms.com\/Portals\/0\/RPS%20document%20library\/Open%20access\/Hospital%20Pharmacy%20Hub\/Learnings%20from%20Gosport%20February%202019.pdf?ver=2019-02-13-100902-563\"><span style=\"font-weight: 400\">resource<\/span><\/a><span style=\"font-weight: 400\"> to support pharmacy to learn the lessons from the <\/span><a href=\"https:\/\/www.gosportpanel.independent.gov.uk\/panel-report\/\"><span style=\"font-weight: 400\">Gosport Independent Panel report<\/span><\/a><span style=\"font-weight: 400\">, which was published in June 2018. In addition, the Royal Pharmaceutical Society\u2019s Hospital Expert Advisory Group has published a <\/span><a href=\"https:\/\/www.rpharms.com\/about-us\/who-we-are\/expert-advisors\/hospital-expert-advisory-group\/gosport-report\"><span style=\"font-weight: 400\">discussion paper<\/span><\/a><span style=\"font-weight: 400\"> on areas requiring action.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3>DRUG UPDATES<\/h3>\n<p><b>Glycopyrronium 1mg\/5mL oral solution updated indications<\/b><\/p>\n<p><span style=\"font-weight: 400\">Glycopyrronium bromide 1mg\/5mLoral solution (Colonis Pharma) is now authorized in the UK for the treatment of <\/span><span style=\"font-weight: 400\">severe in children and adolescents \u2265 3 years with chronic neurological disorders. Previously, only the Sialanar<\/span><span style=\"font-weight: 400\">\u00ae<\/span><span style=\"font-weight: 400\"> product (Glycopyrronium bromide 2mg\/5mL) was authorized for this indication. For the SPC, click <\/span><a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/7344\/smpc\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3>LATEST ADDITIONS<\/h3>\n<p><b>Strong opioid TD patch monitoring chart<\/b><\/p>\n<p><span style=\"font-weight: 400\">palliativedrugs.com strong opioid transdermal (TD) patch monitoring chart has been updated and added to the Document library under the topic of Pain (strong opioids). This 2019 version supersedes the previous version from 2017 which has now been removed. Click <\/span><a href=\"https:\/\/www.palliativedrugs.com\/latest\/2019\/january.html\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>Prevention of SRE survey?<\/b><\/p>\n<p><span style=\"font-weight: 400\">Results are available from our survey, on the prevention of skeletal-related events in adults with bone metastases from solid tumours, on the Latest additions section of the www.palliativedrugs.com website. Click <\/span><a href=\"https:\/\/www.palliativedrugs.com\/latest\/march\/prevention-of-skeletal-related-events-sre-in-adults-with-bone-metastases-from-solid-tumours-what-do-you-use.html\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>PCF updated monographs<\/b><\/p>\n<p><span style=\"font-weight: 400\">The on-line PCF is being continually updated. Some of the website monographs now supersede those in the print publication of the 6th edition of the Palliative Care Formulary (PCF6). During January to March 2019 the following monographs have been updated and can be accessed on the <\/span><a href=\"https:\/\/about.medicinescomplete.com\/publication\/palliative-care-formulary\/\"><span style=\"font-weight: 400\">MedicinesComplete<\/span><\/a><span style=\"font-weight: 400\"> website:<\/span><\/p>\n<p><span style=\"font-weight: 400\">Chapter 01: Loperamide (minor update), Pancreatin<\/span><\/p>\n<p><span style=\"font-weight: 400\">Chapter 04: \u00a0Antidepressants (minor update), Mirtazapine (minor update), Olanzapine (minor update), Levetiracetam (minor update)<\/span><\/p>\n<p><span style=\"font-weight: 400\">Chapter 08: \u00a0Catheter patency solutions<\/span><\/p>\n<p><span style=\"font-weight: 400\">Chapter 09: \u00a0Zinc<\/span><\/p>\n<p><span style=\"font-weight: 400\">Chapter 20: QT prolongation<\/span><\/p>\n<p><span style=\"font-weight: 400\">A <\/span><a href=\"https:\/\/www.palliativedrugs.com\/latest\/march\/on-line-pcf-updated-monographs-summary-february-2019.html\"><span style=\"font-weight: 400\">full list<\/span><\/a><span style=\"font-weight: 400\"> of all the monographs updated since the publication of PCF6 can be found on the Latest additions section of the www.palliativedrugs.com website, along with more details of the minor updates. In addition, follow @palliativedrugs on twitter for the latest updates.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400\">Prepared by Sarah Charlesworth and Andrew Wilcock<\/span><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Selected items from the News and Latest Additions sections of www.palliativedrugs.com, the world\u2019s leading palliative care website with over 30,000 members from 169 Countries. SAFETY UPDATES CME T34 syringe pumps now require foam pads to be added to the battery compartment All Caesarea Medical Electronics (CME) T34 Ambulatory syringe pumps in the UK now need [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/spcare\/2019\/04\/17\/news-and-updates-from-www-palliativedrugs-com-106\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":357,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1141,2833],"tags":[],"class_list":["post-1393","post","type-post","status-publish","format-standard","hentry","category-news","category-updates-from-www-palliativedrugs-com"],"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts\/1393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/users\/357"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/comments?post=1393"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts\/1393\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/media?parent=1393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/categories?post=1393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/tags?post=1393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}