{"id":1362,"date":"2018-07-30T14:43:23","date_gmt":"2018-07-30T14:43:23","guid":{"rendered":"https:\/\/blogs.bmj.com\/spcare\/?p=1362"},"modified":"2018-07-11T14:44:17","modified_gmt":"2018-07-11T14:44:17","slug":"shortcuts-95","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/spcare\/2018\/07\/30\/shortcuts-95\/","title":{"rendered":"Shortcuts"},"content":{"rendered":"<p><strong>Effects of smoking and body mass index on the exposure of fentanyl in patients with cancer.<\/strong><\/p>\n<p>Kuip EJM, Oldenmenger WH, Thijs-Visser MF, de Bruijn P, Oosten AW, Oomen-de Hoop E, Koolen SLW, Van der Rijt CCD, Mathijssen RHJ.<\/p>\n<p>PLoS One. 2018 Jun 8;13(6):e0198289<\/p>\n<p>A prospective single-centre pharmacokinetic study examined the effect of smoking and body mass index (BMI) in cancer patients on a stable dose of transdermal fentanyl patch. Eighty-eight patients with a median age of 59.5 years completed this; 27 patients were smokers; 20 patients had a BMI &lt; 20 kg\/m<sup>2<\/sup>, 41 patients had BMI between 20-25 kg\/m<sup>2<\/sup>\u00a0and 27 patients had a BMI &gt; 25 kg\/m<sup>2<\/sup>. The normalized plasma concentrations of fentanyl were 27.7% higher in non-smokers than smokers, although this was not statistically significant (p = 0.32). BMI did not affect the plasma concentration of fentanyl. The authors report that the inter-individual variation in plasma fentanyl levels was larger than anticipated and therefore studies with larger numbers are needed.<\/p>\n<p>Composed by Elaine Boland.<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Effects of smoking and body mass index on the exposure of fentanyl in patients with cancer. Kuip EJM, Oldenmenger WH, Thijs-Visser MF, de Bruijn P, Oosten AW, Oomen-de Hoop E, Koolen SLW, Van der Rijt CCD, Mathijssen RHJ. PLoS One. 2018 Jun 8;13(6):e0198289 A prospective single-centre pharmacokinetic study examined the effect of smoking and body [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/spcare\/2018\/07\/30\/shortcuts-95\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":275,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1982],"tags":[],"class_list":["post-1362","post","type-post","status-publish","format-standard","hentry","category-short-cuts"],"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts\/1362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/users\/275"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/comments?post=1362"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts\/1362\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/media?parent=1362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/categories?post=1362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/tags?post=1362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}