{"id":1095,"date":"2015-12-18T13:59:44","date_gmt":"2015-12-18T13:59:44","guid":{"rendered":"https:\/\/blogs.bmj.com\/spcare\/?p=1095"},"modified":"2015-12-18T13:59:44","modified_gmt":"2015-12-18T13:59:44","slug":"shortcuts-65","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/spcare\/2015\/12\/18\/shortcuts-65\/","title":{"rendered":"Shortcuts"},"content":{"rendered":"<p><strong>J Clin Oncol. 2015 Dec 7. pii: JCO.2015.63.8221. [Epub ahead of print]<\/strong><\/p>\n<p><strong><a href=\"http:\/\/jco.ascopubs.org\/content\/early\/2015\/12\/07\/JCO.2015.63.8221.abstract\" target=\"_blank\">Randomized Double-Blind Trial of Pregabalin Versus Placebo in Conjunction With Palliative Radiotherapy for Cancer-Induced Bone Pain.<\/a><\/strong><\/p>\n<p><strong>Fallon M, Hoskin PJ, Colvin LA, et al<\/strong><\/p>\n<p>In a multicenter, double-blind randomized trial in adults with moderate to severely painful radiologically-proven bone metastases, due to receive radiotherapy, pregabalin (titrated over 4 weeks) was compared to placebo. From nearly 2000 patients screened, 233 were randomly assigned (the target was 260): 117 to placebo and 116 to pregabalin; all were included in the analysis. Patients had a variety of cancers, with prostate, breast and lung being the most common. In the pregabalin arm, 45 patients (39%) had a reduction of \u2265 2 points in worst pain by week 4 (the primary end point), compared with 47 (40%) in the placebo arm. The secondary end points of average pain, pain interference, or quality of life were also the same between arms. There were significant improvements in mood and a decrease in breakthrough pain episodes with pregabalin. There were no differences in adverse events. This study does not support the routine use of pregabalin in patients with cancer-induced bone pain receiving radiotherapy however future research is needed to evaluate the effect of pregabalin in patients with a neuropathic component to their cancer-induced bone pain.<\/p>\n<p>Shortcuts are compiled by Jason Boland<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>J Clin Oncol. 2015 Dec 7. pii: JCO.2015.63.8221. [Epub ahead of print] Randomized Double-Blind Trial of Pregabalin Versus Placebo in Conjunction With Palliative Radiotherapy for Cancer-Induced Bone Pain. Fallon M, Hoskin PJ, Colvin LA, et al In a multicenter, double-blind randomized trial in adults with moderate to severely painful radiologically-proven bone metastases, due to receive [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/spcare\/2015\/12\/18\/shortcuts-65\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":275,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1982],"tags":[],"class_list":["post-1095","post","type-post","status-publish","format-standard","hentry","category-short-cuts"],"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts\/1095","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/users\/275"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/comments?post=1095"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/posts\/1095\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/media?parent=1095"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/categories?post=1095"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/spcare\/wp-json\/wp\/v2\/tags?post=1095"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}