People with psoriatic arthritis may have low bone mineral density, but the link remains unclear<\/p>\n
INTRODUCTION<\/strong> WHAT DID THE AUTHORS HOPE TO FIND?<\/strong> WHO WAS STUDIED?<\/strong> HOW WAS THE STUDY CONDUCTED?<\/strong> WHAT WERE THE MAIN FINDINGS OF THE STUDY?<\/strong> ARE THESE FINDINGS NEW?<\/strong> WHAT ARE THE LIMITATIONS OF THE STUDY?<\/strong> WHAT DO THE AUTHORS PLAN ON DOING WITH THIS INFORMATION?<\/strong> WHAT DOES THIS MEAN FOR ME?<\/strong> Disclaimer: This is a summary of a scientific article written by a medical professional (\u201cthe Original Article\u201d). The Summary is written to assist non medically trained readers to understand general points of the Original Article. It is supplied \u201cas is\u201d without any warranty. You should note that the Original Article (and Summary) may not be fully relevant nor accurate as medical science is constantly changing and errors can occur. It is therefore very important that readers not rely on the content in the Summary and consult their medical professionals for all aspects of their health care and only rely on the Summary if directed to do so by their medical professional.<\/p>\n Please view our full Website Terms and Conditions.<\/a><\/p>\n Date prepared:<\/strong> October 2020 Copyright \u00a9<\/b>\u00a02020 BMJ Publishing Group Ltd & European League Against Rheumatism. Medical professionals may print copies for their and their patients and students non commercial use. Other individuals may print a single copy for their personal, non commercial use. For other uses please contact our\u00a0Rights and Licensing Team<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":" People with psoriatic arthritis may have low bone mineral density, but the link remains unclear INTRODUCTION Psoriatic arthritis (shortened to PsA) is a chronic inflammatory disease that affects a person\u2019s joints, causing pain and disability. The disease often causes swelling of the fingers and toes. It gets its name from the link between this type […]<\/p>\n
\nPsoriatic arthritis (shortened to PsA) is a chronic inflammatory disease that affects a person\u2019s joints, causing pain and disability. The disease often causes swelling of the fingers and toes. It gets its name from the link between this type of arthritis and a skin condition called psoriasis, which causes redness and scaling. Most people lose bone density as a normal part of ageing. Osteoporosis is a condition where a person\u2019s bone density is reduced, making their bones fragile and more likely to fracture (break). Hip, spine (back) and wrist fractures are the most common types of fracture in people with osteoporosis.<\/p>\n
\nThe authors wanted to find out whether people with psoriasis or psoriatic arthritis are more likely to have low bone mineral density, osteoporosis or fractures. They also hoped to be able to show if there is a genetic link between psoriasis and osteoporosis.<\/p>\n
\nThe study looked at samples from 4,904 people with psoriasis and 847 people with psoriatic arthritis.<\/p>\n
\nThis was an observational study. This means that the authors looked at existing information stored in UK Biobank databases. There was no intervention being tested. 4,904 people with psoriasis and 847 people with or psoriatic arthritis were identified from over 400,000 medical records. From these data the researchers could test if these people developed low bone mineral density or osteoporosis.<\/p>\n
\nThe main finding was that psoriatic arthritis might be a risk factor for low bone mineral density, but the link was not genetically determined. The analysis suggest that other factors such as treatment with methotrexate or ciclosporin might reduce bone mineral density. Having reduced physical activity due to arthritis also had an important effect. No difference in bone mineral density was found between people with psoriasis (no arthritis) and people without the disease.<\/p>\n
\nYes. They found that psoriasis by itself is not a risk factor for osteoporosis. For people with psoriatic arthritis, the link is still unclear.<\/p>\n
\nOne limitation is that people\u2019s bone mineral density was estimated by a type of imaging called quantitative ultrasound, but a different technique called dual-energy X-ray absorptiometry (DXA for short) might work better. In addition, the authors did not have access to all information about the disease activity of people with psoriasis.<\/p>\n
\nThe authors would like to do further studies using DXA to check the association between psoriatic arthritis and bone mineral density. They would also like to investigate how methotrexate affects bone.<\/p>\n
\nIf you have psoriatic arthritis and receive treatment with methotrexate or ciclosporin, you might be more at risk of developing osteoporosis. Your doctor might suggest checking your bone mineral density. You can take steps to improve your bone health by doing regular exercise and eating a healthy, balanced diet. To find out the best options for you, talk to your doctor.<\/p>\n
\nSummary based on research article published on:<\/strong> 31 July 2020
\nFrom:<\/strong> Xia J, et al. Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and mendelian randomization study. Ann Rheum Dis 2020;79:1460\u20131467. doi: 10.1136\/annrheumdis-2020-217892.<\/p>\n