{"id":2869,"date":"2015-01-08T10:59:04","date_gmt":"2015-01-08T09:59:04","guid":{"rendered":"https:\/\/blogs.bmj.com\/medical-ethics\/?p=2869"},"modified":"2015-01-08T10:59:04","modified_gmt":"2015-01-08T09:59:04","slug":"in-the-journal-the-ethics-of-molecular-memory-modification","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/medical-ethics\/2015\/01\/08\/in-the-journal-the-ethics-of-molecular-memory-modification\/","title":{"rendered":"In the Journal: The Ethics of Molecular Memory Modification"},"content":{"rendered":"<p><strong>Guest post by\u00a0<span class=\"Apple-style-span\">Katrina Hui<\/span><\/strong><\/p>\n<p>What if memories could be enhanced or erased, not through traditional pharmaceuticals, but directly, through manipulation of the molecular processes that govern memory?<\/p>\n<p>Several years ago, scientists thought they had found a single molecule believed to be the key to memory editing. This molecule, called protein kinase M\u03b6 (PKM\u03b6), appeared to play a crucial role in the preservation of specific long-term memories. Though its actual molecular mechanism remains unclear, the discovery demonstrates that memory is governed by molecular processes and can possibly be manipulated through such means. Though research is still in its early stages, the example of molecular memory modification raises some interesting questions about the ethics of memory that merit consideration.<\/p>\n<p>According to current frameworks of memory, memories are made temporarily unstable after recall and are \u201crewritten\u201d each time they are summoned before being stored again. Early research seemed to indicate that specific memories could be enhanced by increasing levels of PKM\u03b6, then recalling the target memories. On the flip side, memories could be \u201cerased\u201d by interfering with the expression of the molecule at a similar point in time in the recall process, thus destabilizing and preventing the re-storage of previously held memories. To add to the excitement, modifying specific memories with PKM\u03b6 seemed to have few side effects on other memories or processes.<\/p>\n<p>However, more recent research has called into question PKM\u03b6\u2019s involvement in long-term memory storage and maintenance, and it remains unclear if PKM\u03b6 really is as powerful as it was once thought to be.<\/p>\n<p>Nonetheless, the possibility of manipulating memory through molecular means will continue to be investigated. Molecular memory modification (MMM) provides a new perspective on some unresolved ethical questions regarding memory. For instance, is there a \u201cthe duty to remember\u201d certain valuable memories? This duty could have a place in the courtroom, for example, where eyewitness testimony, while notoriously unreliable, is also frequently used and sometimes essential. On the other hand, while requiring or perhaps even forcing people to remember might appeal to those with an authoritarian bent, in reality, the mechanism of action of MMM in particular requires active recall from the participant, illustrating how subject participation, a previously neglected topic in ethical debates about memory, could be essential.<\/p>\n<p>More broadly, the example of MMM illustrates that the idea of \u201cenhancing\u201d memory, rather than a monolithic process, is multifaceted. The folk intuition of enhancing memory, generally implies remembering more, for a longer time. However, a closer examination of the molecular processes underlying memory functions, the term \u201cenhancement\u201d is shown to be vague, as there are many dimensions along which memory could be enhanced, such as fixing incorrect associations, eliminating temporary memory blocks, or even erasing memories in cases such as Post-Traumatic Stress Disorder. What ethical concerns are relevant and we mean when we use the term \u201cenhancement\u201d ultimately depends on <em>how<\/em> memories are altered. As research continues, new mechanisms for improving memory will emerge, and more precision about the ethical calculus will be required.<\/p>\n<p>&nbsp;<\/p>\n<p><em>Read the full paper <a href=\"http:\/\/jme.bmj.com\/content\/early\/2014\/12\/31\/medethics-2013-101891.full.pdf+html\"><span style=\"color: #0000ff\">here<\/span><\/a>.<\/em><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Guest post by\u00a0Katrina Hui What if memories could be enhanced or erased, not through traditional pharmaceuticals, but directly, through manipulation of the molecular processes that govern memory? Several years ago, scientists thought they had found a single molecule believed to be the key to memory editing. This molecule, called protein kinase M\u03b6 (PKM\u03b6), appeared to [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/medical-ethics\/2015\/01\/08\/in-the-journal-the-ethics-of-molecular-memory-modification\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2153,443],"tags":[],"class_list":["post-2869","post","type-post","status-publish","format-standard","hentry","category-guest-post","category-jme"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>In the Journal: The Ethics of Molecular Memory Modification - Journal of Medical Ethics blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/medical-ethics\/2015\/01\/08\/in-the-journal-the-ethics-of-molecular-memory-modification\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In the Journal: The Ethics of Molecular Memory Modification - Journal of Medical Ethics blog\" \/>\n<meta property=\"og:description\" content=\"Guest post by\u00a0Katrina Hui What if memories could be enhanced or erased, not through traditional pharmaceuticals, but directly, through manipulation of the molecular processes that govern memory? 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