{"id":444,"date":"2014-08-27T05:53:23","date_gmt":"2014-08-27T05:53:23","guid":{"rendered":"https:\/\/blogs.bmj.com\/jnnp\/?p=444"},"modified":"2014-08-27T05:53:23","modified_gmt":"2014-08-27T05:53:23","slug":"ppms-factors-governing-its-progression","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/","title":{"rendered":"PPMS:  Factors governing its progression"},"content":{"rendered":"<p>Primary progressive MS (PPMS) is the least frequent but possibly the most devastating of the MS phenotypes. The rate of progression and disability accumulation in PPMS has been a matter of debate. In an upcoming issue of JNNP 9Published as first online), Koch and colleagues address the issue of factors governing disability progression. Importantly, older age at onset and bilateral lower limb motor features (spasticity and weakness) seemed to be independent predictors of faster rates of disability accumulation in PPMS. Interestingly, no evidence of distinct phase of disability accumulation were noted in PPMS, contrasting with RRMS. Undoubtedly, this would have impact on the understanding of disease pathogenesis and development of prognostic biomarkers.<\/p>\n<p>&nbsp;<\/p>\n<p>Must read more at:http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/04\/jnnp-2014-307948.abstract<\/p>\n<p>&nbsp;<\/p>\n<div id=\"slugline\"><cite><span id=\"article-slug-jnl-abbr\"><abbr class=\"slug-jnl-abbrev\" title=\"Journal of Neurology, Neurosurgery &amp; Psychiatry\"> Neurol Neurosurg Psychiatry<\/abbr> <\/span> <span class=\"slug-doi\" title=\"10.1136\/jnnp-2014-307948\"> doi:10.1136\/jnnp-2014-307948 <\/span> <\/cite><\/div>\n<ul class=\"subject-headings last-child\">\n<li>Multiple sclerosis<\/li>\n<\/ul>\n<ul class=\"series-titles\">\n<li>Research paper<\/li>\n<\/ul>\n<div class=\"article abstract-view \">\n<h1 id=\"article-title-1\">The natural history of early versus late disability accumulation in primary progressive MS<\/h1>\n<div class=\"contributors\">\n<ol id=\"contrib-group-1\" class=\"contributor-list\">\n<li id=\"contrib-1\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Marcus+W+Koch&amp;sortspec=date&amp;submit=Submit\">Marcus W Koch<\/a><\/span><a id=\"xref-aff-1-1\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/04\/jnnp-2014-307948.abstract#aff-1\">1<\/a><span class=\"xref-sep\">,<\/span><a id=\"xref-aff-2-1\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/04\/jnnp-2014-307948.abstract#aff-2\">2<\/a>,<\/li>\n<li id=\"contrib-2\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Jamie+Greenfield&amp;sortspec=date&amp;submit=Submit\">Jamie Greenfield<\/a><\/span><a id=\"xref-aff-1-2\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/04\/jnnp-2014-307948.abstract#aff-1\">1<\/a>,<\/li>\n<li id=\"contrib-3\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Omid+Javizian&amp;sortspec=date&amp;submit=Submit\">Omid Javizian<\/a><\/span><a id=\"xref-aff-1-3\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/04\/jnnp-2014-307948.abstract#aff-1\">1<\/a>,<\/li>\n<li id=\"contrib-4\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Stephanie+Deighton&amp;sortspec=date&amp;submit=Submit\">Stephanie Deighton<\/a><\/span><a id=\"xref-aff-1-4\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/04\/jnnp-2014-307948.abstract#aff-1\">1<\/a>,<\/li>\n<li id=\"contrib-5\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Winona+Wall&amp;sortspec=date&amp;submit=Submit\">Winona Wall<\/a><\/span><a id=\"xref-aff-1-5\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/04\/jnnp-2014-307948.abstract#aff-1\">1<\/a>,<\/li>\n<li id=\"contrib-6\" class=\"last\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Luanne+M+Metz&amp;sortspec=date&amp;submit=Submit\">Luanne M Metz<\/a><\/span><a id=\"xref-aff-1-6\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/04\/jnnp-2014-307948.abstract#aff-1\">1<\/a><\/li>\n<\/ol>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Primary progressive MS (PPMS) is the least frequent but possibly the most devastating of the MS phenotypes. The rate of progression and disability accumulation in PPMS has been a matter of debate. In an upcoming issue of JNNP 9Published as first online), Koch and colleagues address the issue of factors governing disability progression. Importantly, older [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":160,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-444","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PPMS: Factors governing its progression - JNNP blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PPMS: Factors governing its progression - JNNP blog\" \/>\n<meta property=\"og:description\" content=\"Primary progressive MS (PPMS) is the least frequent but possibly the most devastating of the MS phenotypes. The rate of progression and disability accumulation in PPMS has been a matter of debate. In an upcoming issue of JNNP 9Published as first online), Koch and colleagues address the issue of factors governing disability progression. Importantly, older [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/\" \/>\n<meta property=\"og:site_name\" content=\"JNNP blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-08-27T05:53:23+00:00\" \/>\n<meta name=\"author\" content=\"Steve Vucic, Web Editor\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Steve Vucic, Web Editor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/\"},\"author\":{\"name\":\"Steve Vucic, Web Editor\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#\\\/schema\\\/person\\\/5b9f797a427758da9d63182166e6458c\"},\"headline\":\"PPMS: Factors governing its progression\",\"datePublished\":\"2014-08-27T05:53:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/\"},\"wordCount\":171,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/\",\"name\":\"PPMS: Factors governing its progression - JNNP blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#website\"},\"datePublished\":\"2014-08-27T05:53:23+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/2014\\\/08\\\/27\\\/ppms-factors-governing-its-progression\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"PPMS: Factors governing its progression\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/\",\"name\":\"JNNP blog\",\"description\":\"The official JNNP blog. A place to discuss wider neurology beyond the journal&#039;s monthly edition.\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#organization\",\"name\":\"JNNP blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/files\\\/2017\\\/11\\\/blog-logo-jnnp1.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/files\\\/2017\\\/11\\\/blog-logo-jnnp1.png\",\"width\":427,\"height\":34,\"caption\":\"JNNP blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/#\\\/schema\\\/person\\\/5b9f797a427758da9d63182166e6458c\",\"name\":\"Steve Vucic, Web Editor\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8e68076dae6fcffc1703a9f57f705b2f6f05335487da4d73145fa337d10c9b5a?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8e68076dae6fcffc1703a9f57f705b2f6f05335487da4d73145fa337d10c9b5a?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8e68076dae6fcffc1703a9f57f705b2f6f05335487da4d73145fa337d10c9b5a?s=96&d=mm&r=g\",\"caption\":\"Steve Vucic, Web Editor\"},\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jnnp\\\/author\\\/svucic\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PPMS: Factors governing its progression - JNNP blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/","og_locale":"en_US","og_type":"article","og_title":"PPMS: Factors governing its progression - JNNP blog","og_description":"Primary progressive MS (PPMS) is the least frequent but possibly the most devastating of the MS phenotypes. The rate of progression and disability accumulation in PPMS has been a matter of debate. In an upcoming issue of JNNP 9Published as first online), Koch and colleagues address the issue of factors governing disability progression. Importantly, older [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/","og_site_name":"JNNP blog","article_published_time":"2014-08-27T05:53:23+00:00","author":"Steve Vucic, Web Editor","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Steve Vucic, Web Editor","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/"},"author":{"name":"Steve Vucic, Web Editor","@id":"https:\/\/blogs.bmj.com\/jnnp\/#\/schema\/person\/5b9f797a427758da9d63182166e6458c"},"headline":"PPMS: Factors governing its progression","datePublished":"2014-08-27T05:53:23+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/"},"wordCount":171,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jnnp\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/","url":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/","name":"PPMS: Factors governing its progression - JNNP blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jnnp\/#website"},"datePublished":"2014-08-27T05:53:23+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/27\/ppms-factors-governing-its-progression\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jnnp\/"},{"@type":"ListItem","position":2,"name":"PPMS: Factors governing its progression"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jnnp\/#website","url":"https:\/\/blogs.bmj.com\/jnnp\/","name":"JNNP blog","description":"The official JNNP blog. A place to discuss wider neurology beyond the journal&#039;s monthly edition.","publisher":{"@id":"https:\/\/blogs.bmj.com\/jnnp\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jnnp\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jnnp\/#organization","name":"JNNP blog","url":"https:\/\/blogs.bmj.com\/jnnp\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jnnp\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jnnp\/files\/2017\/11\/blog-logo-jnnp1.png","contentUrl":"https:\/\/blogs.bmj.com\/jnnp\/files\/2017\/11\/blog-logo-jnnp1.png","width":427,"height":34,"caption":"JNNP blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jnnp\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jnnp\/#\/schema\/person\/5b9f797a427758da9d63182166e6458c","name":"Steve Vucic, Web Editor","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/8e68076dae6fcffc1703a9f57f705b2f6f05335487da4d73145fa337d10c9b5a?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/8e68076dae6fcffc1703a9f57f705b2f6f05335487da4d73145fa337d10c9b5a?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8e68076dae6fcffc1703a9f57f705b2f6f05335487da4d73145fa337d10c9b5a?s=96&d=mm&r=g","caption":"Steve Vucic, Web Editor"},"url":"https:\/\/blogs.bmj.com\/jnnp\/author\/svucic\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/posts\/444","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/users\/160"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/comments?post=444"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/posts\/444\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/media?parent=444"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/categories?post=444"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jnnp\/wp-json\/wp\/v2\/tags?post=444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}