{"id":443,"date":"2014-08-22T05:32:42","date_gmt":"2014-08-22T05:32:42","guid":{"rendered":"https:\/\/blogs.bmj.com\/jnnp\/?p=443"},"modified":"2014-08-22T05:32:42","modified_gmt":"2014-08-22T05:32:42","slug":"cortical-thickness-a-biomarker-of-upper-motor-neuron-dysfunction","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/22\/cortical-thickness-a-biomarker-of-upper-motor-neuron-dysfunction\/","title":{"rendered":"Cortical thickness: A biomarker of upper motor neuron dysfunction?"},"content":{"rendered":"<p>Thinning of the motor cortex has been suggested as a biomarker of cortical dysfunction in ALS, although the specificity of the finding remains to be determined. In an upcoming issue of JNNP Walhout and colleagues report on the fact that cortical thinning was a specific feature in ALS, related to pathology of upper motor neurons. Consequently, the possibility of cortical thickness measures serving as potential biomarkers of ALS remains very real.<\/p>\n<p>&nbsp;<\/p>\n<p>Must read more at:\u00a0 http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/13\/jnnp-2013-306839.abstract<\/p>\n<p>&nbsp;<\/p>\n<div id=\"slugline\"><cite> <span id=\"article-slug-jnl-abbr\"> <abbr class=\"slug-jnl-abbrev\" title=\"Journal of Neurology, Neurosurgery &amp; Psychiatry\"> J Neurol Neurosurg Psychiatry<\/abbr> <\/span> <span class=\"slug-doi\" title=\"10.1136\/jnnp-2013-306839\"> doi:10.1136\/jnnp-2013-306839 <\/span> <\/cite><\/div>\n<ul class=\"subject-headings last-child\">\n<li>Neuromuscular<\/li>\n<\/ul>\n<ul class=\"series-titles\">\n<li>Research paper<\/li>\n<\/ul>\n<div class=\"article abstract-view \">\n<h1 id=\"article-title-1\">Cortical thickness in ALS: towards a marker for upper motor neuron involvement<\/h1>\n<div class=\"contributors\">\n<ol id=\"contrib-group-1\" class=\"contributor-list\">\n<li id=\"contrib-1\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Ren%C3%A9e+Walhout&amp;sortspec=date&amp;submit=Submit\">Ren\u00e9e Walhout<\/a><\/span><a id=\"xref-aff-1-1\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/13\/jnnp-2013-306839.abstract#aff-1\">1<\/a>,<\/li>\n<li id=\"contrib-2\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Henk-Jan+Westeneng&amp;sortspec=date&amp;submit=Submit\">Henk-Jan Westeneng<\/a><\/span><a id=\"xref-aff-1-2\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/13\/jnnp-2013-306839.abstract#aff-1\">1<\/a>,<\/li>\n<li id=\"contrib-3\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Esther+Verstraete&amp;sortspec=date&amp;submit=Submit\">Esther Verstraete<\/a><\/span><a id=\"xref-aff-1-3\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/13\/jnnp-2013-306839.abstract#aff-1\">1<\/a>,<\/li>\n<li id=\"contrib-4\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Jeroen+Hendrikse&amp;sortspec=date&amp;submit=Submit\">Jeroen Hendrikse<\/a><\/span><a id=\"xref-aff-2-1\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/13\/jnnp-2013-306839.abstract#aff-2\">2<\/a>,<\/li>\n<li id=\"contrib-5\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Jan+H+Veldink&amp;sortspec=date&amp;submit=Submit\">Jan H Veldink<\/a><\/span><a id=\"xref-aff-1-4\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/13\/jnnp-2013-306839.abstract#aff-1\">1<\/a>,<\/li>\n<li id=\"contrib-6\" class=\"contributor\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Martijn+P+van+den+Heuvel&amp;sortspec=date&amp;submit=Submit\">Martijn P van den Heuvel<\/a><\/span><a id=\"xref-aff-3-1\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/13\/jnnp-2013-306839.abstract#aff-3\">3<\/a>,<\/li>\n<li id=\"contrib-7\" class=\"last\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Leonard+H+van+den+Berg&amp;sortspec=date&amp;submit=Submit\">Leonard H van den Berg<\/a><\/span><a id=\"xref-aff-1-5\" class=\"xref-aff\" href=\"http:\/\/jnnp.bmj.com\/content\/early\/2014\/08\/13\/jnnp-2013-306839.abstract#aff-1\">1<\/a><\/li>\n<\/ol>\n<\/div>\n<\/div>\n<p><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thinning of the motor cortex has been suggested as a biomarker of cortical dysfunction in ALS, although the specificity of the finding remains to be determined. In an upcoming issue of JNNP Walhout and colleagues report on the fact that cortical thinning was a specific feature in ALS, related to pathology of upper motor neurons. [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/22\/cortical-thickness-a-biomarker-of-upper-motor-neuron-dysfunction\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":160,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-443","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cortical thickness: A biomarker of upper motor neuron dysfunction? - JNNP blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/08\/22\/cortical-thickness-a-biomarker-of-upper-motor-neuron-dysfunction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cortical thickness: A biomarker of upper motor neuron dysfunction? - JNNP blog\" \/>\n<meta property=\"og:description\" content=\"Thinning of the motor cortex has been suggested as a biomarker of cortical dysfunction in ALS, although the specificity of the finding remains to be determined. In an upcoming issue of JNNP Walhout and colleagues report on the fact that cortical thinning was a specific feature in ALS, related to pathology of upper motor neurons. 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