{"id":383,"date":"2014-05-08T03:34:28","date_gmt":"2014-05-08T03:34:28","guid":{"rendered":"https:\/\/blogs.bmj.com\/jnnp\/?p=383"},"modified":"2014-05-08T03:34:28","modified_gmt":"2014-05-08T03:34:28","slug":"autologous-haematopoietic-stem-cell-transplantation-in-cidp-taking-a-hammer-to-the-walnut","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jnnp\/2014\/05\/08\/autologous-haematopoietic-stem-cell-transplantation-in-cidp-taking-a-hammer-to-the-walnut\/","title":{"rendered":"Autologous haematopoietic stem cell transplantation in CIDP: Taking a hammer to the walnut?"},"content":{"rendered":"<p>Chronic inflammatory demyelinating neuropathy (CIDP) remains a difficult disorder to treat, particularly when patients fail to respond to one of the first line therapies.\u00a0 In addition, complications relating steroid and impressive treatments remain high \u00a0\u00a0 and disability for this disorder is invariably a difficult management problem.\u00a0 In the June issue of JNNP, the utility of autologous stem cell transplantation was investigated.\u00a0 In a small study Press and colleagues report on clinical improvement in CIDP patients 2-6 months after therapy.\u00a0 However, a substantial proportion relapsed requiring further treatment and the complications were potentially serious, including pancreatitis and hemorrhagic cystitis.<\/p>\n<p>The question of therapeutic utility remains, particularly selecting the appropriate patient.\u00a0 Further studies are clearly needed, but none-the-less this is a must read article for the neuromuscular physicians.<\/p>\n<p>&nbsp;<\/p>\n<p>http:\/\/jnnp.bmj.com\/content\/85\/6\/618.abstract<\/p>\n<p>&nbsp;<\/p>\n<div class=\"cit-metadata\">\n<h4 class=\"cit-first-element cit-title-group\"><span class=\"cit-series-title\">Research paper<span class=\"cit-sep cit-sep-after-article-series-title\">:<\/span> <\/span>Autologous haematopoietic stem cell transplantation: a viable treatment option for CIDP<\/h4>\n<ul class=\"cit-auth-list\">\n<li class=\"first-item\"><span class=\"cit-auth cit-auth-type-author\">R Press<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li><span class=\"cit-auth cit-auth-type-author\">H Askmark<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li><span class=\"cit-auth cit-auth-type-author\">A Svenningsson<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li><span class=\"cit-auth cit-auth-type-author\">O Andersen<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li><span class=\"cit-auth cit-auth-type-author\">H W Axelson<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li><span class=\"cit-auth cit-auth-type-author\">U Str\u00f6mberg<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li><span class=\"cit-auth cit-auth-type-author\">A Wahlin<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li><span class=\"cit-auth cit-auth-type-author\">C Isaksson<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li><span class=\"cit-auth cit-auth-type-author\">J-E J Johansson<\/span><span class=\"cit-sep cit-sep-separator\">, <\/span><\/li>\n<li class=\"last-item\"><span class=\"cit-auth cit-auth-type-author\">H H\u00e4gglund<\/span><\/li>\n<\/ul>\n<p><cite><abbr class=\"site-title\" title=\"Journal of Neurology, Neurosurgery &amp; Psychiatry\">J Neurol Neurosurg Psychiatry<\/abbr> <span class=\"cit-print-date\">2014<span class=\"cit-sep cit-sep-after-article-print-date\">;<\/span><\/span><span class=\"cit-vol\">85<span class=\"cit-sep cit-sep-after-article-vol\">:<\/span><\/span><span class=\"cit-pages\"><span class=\"cit-first-page\">618<\/span><span class=\"cit-sep\">&#8211;<\/span><span class=\"cit-last-page\">624<\/span><\/span><span class=\"cit-ahead-of-print-date\"><span class=\"cit-sep cit-sep-before-article-ahead-of-print-date\">Published Online First: <\/span>21 November 2013 <\/span><span class=\"cit-doi\"><span class=\"cit-sep cit-sep-before-article-doi\">doi:<\/span>10.1136\/jnnp-2013-306014 <\/span><\/cite><\/div>\n<p><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chronic inflammatory demyelinating neuropathy (CIDP) remains a difficult disorder to treat, particularly when patients fail to respond to one of the first line therapies.\u00a0 In addition, complications relating steroid and impressive treatments remain high \u00a0\u00a0 and disability for this disorder is invariably a difficult management problem.\u00a0 In the June issue of JNNP, the utility of [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/05\/08\/autologous-haematopoietic-stem-cell-transplantation-in-cidp-taking-a-hammer-to-the-walnut\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":160,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-383","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Autologous haematopoietic stem cell transplantation in CIDP: Taking a hammer to the walnut? - JNNP blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/05\/08\/autologous-haematopoietic-stem-cell-transplantation-in-cidp-taking-a-hammer-to-the-walnut\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Autologous haematopoietic stem cell transplantation in CIDP: Taking a hammer to the walnut? - JNNP blog\" \/>\n<meta property=\"og:description\" content=\"Chronic inflammatory demyelinating neuropathy (CIDP) remains a difficult disorder to treat, particularly when patients fail to respond to one of the first line therapies.\u00a0 In addition, complications relating steroid and impressive treatments remain high \u00a0\u00a0 and disability for this disorder is invariably a difficult management problem.\u00a0 In the June issue of JNNP, the utility of [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/05\/08\/autologous-haematopoietic-stem-cell-transplantation-in-cidp-taking-a-hammer-to-the-walnut\/\" \/>\n<meta property=\"og:site_name\" content=\"JNNP blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-05-08T03:34:28+00:00\" \/>\n<meta name=\"author\" content=\"Steve Vucic, Web Editor\" 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