{"id":371,"date":"2014-04-29T13:32:05","date_gmt":"2014-04-29T13:32:05","guid":{"rendered":"https:\/\/blogs.bmj.com\/jnnp\/?p=371"},"modified":"2014-04-29T13:32:34","modified_gmt":"2014-04-29T13:32:34","slug":"a-novel-dorsl-root-ganglionopathy-canvas-syndrome","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jnnp\/2014\/04\/29\/a-novel-dorsl-root-ganglionopathy-canvas-syndrome\/","title":{"rendered":"A novel dorsal root ganglionopathy: CANVAS syndrome"},"content":{"rendered":"

Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) syndrome is\u00a0 a novel cerebellar ataxia clinically characterized by a combination of cerebellar dysfunction, bilateral vestibular dysfunction, and peripheral sensory neuropathy\/neuronopathy.\u00a0 This novel syndrome may be confused with Machado-Joseph disease or Friedreich ataxia, although the genetics remain elusive.<\/p>\n

In the April issue of neurology (22nd April), Professor Halmagyi’s group establish the pathology of this unusual disorder, documenting marked loss of Purkinje cells in the cerbellum, predominantly the vermis, along with degeneration of dorsal columns and dorsal root ganglia.<\/p>\n

 <\/p>\n

Read more at,\u00a0 http:\/\/www.neurology.org\/content\/82\/16\/1410.abstract<\/p>\n

 <\/p>\n

Dorsal root ganglionopathy is responsible for the sensory impairment in CANVAS<\/h1>\n
\n
    \n
  1. David J. Szmulewicz<\/span>, FRACP<\/span>,<\/li>\n
  2. Catriona A. McLean<\/span>, FRCPA<\/span>,<\/li>\n
  3. Michael L. Rodriguez<\/span>, FRCPA<\/span>,<\/li>\n
  4. Andrew M. Chancellor<\/span>, FRACP<\/span>,<\/li>\n
  5. Stuart Mossman<\/span>, FRACP<\/span>,<\/li>\n
  6. Duncan Lamont<\/span>, FRCP<\/span>,<\/li>\n
  7. Leslie Roberts<\/span>, FRACP<\/span>,<\/li>\n
  8. Elsdon Storey<\/span>, FRACP<\/span> and<\/li>\n
  9. G. Michael Halmagyi<\/span>, FRACP<\/span><\/li>\n<\/ol>\n<\/div>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) syndrome is\u00a0 a novel cerebellar ataxia clinically characterized by a combination of cerebellar dysfunction, bilateral vestibular dysfunction, and peripheral sensory neuropathy\/neuronopathy.\u00a0 This novel syndrome may be confused with Machado-Joseph disease or Friedreich ataxia, although the genetics remain elusive. In the April issue of neurology (22nd […]<\/p>\n

    Read More…<\/a><\/p>\n","protected":false},"author":160,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-371","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nA novel dorsal root ganglionopathy: CANVAS syndrome - JNNP blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/04\/29\/a-novel-dorsl-root-ganglionopathy-canvas-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A novel dorsal root ganglionopathy: CANVAS syndrome - JNNP blog\" \/>\n<meta property=\"og:description\" content=\"Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) syndrome is\u00a0 a novel cerebellar ataxia clinically characterized by a combination of cerebellar dysfunction, bilateral vestibular dysfunction, and peripheral sensory neuropathy\/neuronopathy.\u00a0 This novel syndrome may be confused with Machado-Joseph disease or Friedreich ataxia, although the genetics remain elusive. 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