{"id":368,"date":"2014-04-23T13:30:39","date_gmt":"2014-04-23T13:30:39","guid":{"rendered":"https:\/\/blogs.bmj.com\/jnnp\/?p=368"},"modified":"2014-04-23T13:30:39","modified_gmt":"2014-04-23T13:30:39","slug":"multifocal-motor-neuropathy-a-blood-nerve-barrier-disease","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jnnp\/2014\/04\/23\/multifocal-motor-neuropathy-a-blood-nerve-barrier-disease\/","title":{"rendered":"Multifocal motor neuropathy: A blood-nerve barrier disease?"},"content":{"rendered":"

Multifocal motor neuropathy (MMN) is a rare autoimmune disorder of the peripheral motor nerves leading to muscle weakness, secondary to conduction block, and ultimately axonal degeneration.<\/p>\n

Debate emerged over the past decade as to whether MMN is a demyelinating or axonal neuropathy, although the debate seem rather academic as both processes may and do co-exist in a variety of “demyelinating” or better termed “autoimmune” neuropathies.\u00a0 In the May issue of JNNP, Shimizu and colleagues elegantly demonstrate\u00a0 the pathogenesis of sera from MMN patients, pointing to a clear “autoimmune” process.\u00a0 Specifically, sera from MMN patients were shown to disrupt the blood-nerve barrier by up-regulating vascular cell adhesion molecule-1 (VCAM-1) leading to an influx of inflammatory cells.\u00a0 It would be interesting to determine whether IVIg restored the blood-nerve barrier, a potential therapeutic effect, and whether this correlates with clinical improvement.<\/p>\n

 <\/p>\n

Read more at \u00a0 http:\/\/jnnp.bmj.com\/content\/85\/5\/526.abstract<\/p>\n

 <\/p>\n

Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier<\/h1>\n
\n
    \n
  1. Fumitaka Shimizu<\/a><\/span>1<\/a>,<\/li>\n
  2. Masatoshi Omoto<\/a><\/span>1<\/a>,<\/li>\n
  3. Yasuteru Sano<\/a><\/span>1<\/a>,<\/li>\n
  4. Naoko Mastui<\/a><\/span>2<\/a>,<\/li>\n
  5. Ai Miyashiro<\/a><\/span>2<\/a>,<\/li>\n
  6. Ayako Tasaki<\/a><\/span>1<\/a>,<\/li>\n
  7. Toshihiko Maeda<\/a><\/span>1<\/a>,<\/li>\n
  8. Michiaki Koga<\/a><\/span>1<\/a>,<\/li>\n
  9. Ryuji Kaji<\/a><\/span>2<\/a>,<\/li>\n
  10. Takashi Kanda<\/a><\/span>1<\/a><\/li>\n<\/ol>\n<\/div>\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    Multifocal motor neuropathy (MMN) is a rare autoimmune disorder of the peripheral motor nerves leading to muscle weakness, secondary to conduction block, and ultimately axonal degeneration. Debate emerged over the past decade as to whether MMN is a demyelinating or axonal neuropathy, although the debate seem rather academic as both processes may and do co-exist […]<\/p>\n

    Read More…<\/a><\/p>\n","protected":false},"author":160,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-368","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nMultifocal motor neuropathy: A blood-nerve barrier disease? - JNNP blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/04\/23\/multifocal-motor-neuropathy-a-blood-nerve-barrier-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Multifocal motor neuropathy: A blood-nerve barrier disease? - JNNP blog\" \/>\n<meta property=\"og:description\" content=\"Multifocal motor neuropathy (MMN) is a rare autoimmune disorder of the peripheral motor nerves leading to muscle weakness, secondary to conduction block, and ultimately axonal degeneration. 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