{"id":362,"date":"2014-04-10T05:36:42","date_gmt":"2014-04-10T05:36:42","guid":{"rendered":"https:\/\/blogs.bmj.com\/jnnp\/?p=362"},"modified":"2014-04-10T05:36:42","modified_gmt":"2014-04-10T05:36:42","slug":"cns-antibodies-how-useful-are-they","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jnnp\/2014\/04\/10\/cns-antibodies-how-useful-are-they\/","title":{"rendered":"CNS antibodies: How useful are they?"},"content":{"rendered":"<p>The detection of autoantibodies in autoimmune CNS disorders has been if immense interest, with implications for undelrying pathophysiology.\u00a0 A variety of autoantibodies have been detected and associated with various CNS syndromes, although the question remians whether these antibodies are pathogenic, an epiphenomenon, or both.<\/p>\n<p>&nbsp;<\/p>\n<p>In this issue of JNNP, Hacohen and colleagues report on antibody biomakers in CNS demyelinating disorders of childhood.\u00a0 A variety of anibodies and syndromew were reported, with the bottom line being that specific antibodies are associated with specific syndromes.\u00a0 Consequently, the principles of good medical practice remians to define the phenotype and then look for the &#8220;genotype&#8221; or in thid case the antibody.\u00a0 In addition, the relevance of antibodies in the underlying pathophysiology needs further research.<\/p>\n<p>&nbsp;<\/p>\n<p>Do you think it is worthwhile looking for these antibodies?\u00a0 let me know your thoughrs via twitter.<\/p>\n<p>&nbsp;<\/p>\n<p>Read more at http:\/\/jnnp.bmj.com\/content\/85\/4\/456\/T1.expansion.html<\/p>\n<div id=\"slugline\"><cite> <span id=\"article-slug-jnl-abbr\"> <abbr class=\"slug-jnl-abbrev\" title=\"Journal of Neurology, Neurosurgery &amp; Psychiatry\"> J Neurol Neurosurg Psychiatry<\/abbr> <\/span> <span class=\"slug-pub-date\">2014;<\/span><span class=\"slug-vol\">85<span class=\"cit-sep cit-sep-after-article-vol\">:<\/span><\/span><span class=\"slug-pages\">456-461 <\/span> <span class=\"slug-doi\" title=\"10.1136\/jnnp-2013-306411\"> doi:10.1136\/jnnp-2013-306411 <\/span> <\/cite><\/div>\n<ul class=\"subject-headings last-child\">\n<li>Neuro-inflammation<\/li>\n<\/ul>\n<ul class=\"series-titles\">\n<li>Short report<\/li>\n<\/ul>\n<h1 id=\"article-title-1\">Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort<\/h1>\n<ol class=\"contributor-list\" id=\"contrib-group-1\">\n<li class=\"contributor\" id=\"contrib-1\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Yael+Hacohen&amp;sortspec=date&amp;submit=Submit\">Yael Hacohen<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-1-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-1\">1<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-2\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Michael+Absoud&amp;sortspec=date&amp;submit=Submit\">Michael Absoud<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-2-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-2\">2<\/a><span class=\"xref-sep\">,<\/span><a class=\"xref-aff\" id=\"xref-aff-3-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-3\">3<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-3\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Mark+Woodhall&amp;sortspec=date&amp;submit=Submit\">Mark Woodhall<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-1-2\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-1\">1<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-4\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Carole+Cummins&amp;sortspec=date&amp;submit=Submit\">Carole Cummins<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-3-2\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-3\">3<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-5\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Christian+G+De+Goede&amp;sortspec=date&amp;submit=Submit\">Christian G De Goede<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-4-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-4\">4<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-6\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Cheryl+Hemingway&amp;sortspec=date&amp;submit=Submit\">Cheryl Hemingway<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-5-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-5\">5<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-7\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Philip+E+Jardine&amp;sortspec=date&amp;submit=Submit\">Philip E Jardine<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-6-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-6\">6<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-8\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Rachel+Kneen&amp;sortspec=date&amp;submit=Submit\">Rachel Kneen<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-7-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-7\">7<\/a><span class=\"xref-sep\">,<\/span><a class=\"xref-aff\" id=\"xref-aff-8-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-8\">8<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-9\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Michael+G+Pike&amp;sortspec=date&amp;submit=Submit\">Michael G Pike<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-9-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-9\">9<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-10\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=William+P+Whitehouse&amp;sortspec=date&amp;submit=Submit\">William P Whitehouse<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-10-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-10\">10<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-11\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Evangeline+Wassmer&amp;sortspec=date&amp;submit=Submit\">Evangeline Wassmer<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-11-1\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-11\">11<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-12\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Patrick+Waters&amp;sortspec=date&amp;submit=Submit\">Patrick Waters<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-1-3\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-1\">1<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-13\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Angela+Vincent&amp;sortspec=date&amp;submit=Submit\">Angela Vincent<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-1-4\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-1\">1<\/a>,<\/li>\n<li class=\"contributor\" id=\"contrib-14\"><span class=\"name\"><a class=\"name-search\" href=\"http:\/\/jnnp.bmj.com\/search?author1=Ming+Lim&amp;sortspec=date&amp;submit=Submit\">Ming Lim<\/a><\/span><a class=\"xref-aff\" id=\"xref-aff-1-5\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-1\">1<\/a><span class=\"xref-sep\">,<\/span><a class=\"xref-aff\" id=\"xref-aff-2-2\" href=\"http:\/\/jnnp.bmj.com\/content\/85\/4\/456.full#aff-2\">2<\/a>,<\/li>\n<li class=\"last\" id=\"contrib-15\"><span class=\"collab\" id=\"collab-1\">On behalf of UK &amp; Ireland Childhood CNS Inflammatory Demyelination Working Group<\/span><\/li>\n<\/ol>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The detection of autoantibodies in autoimmune CNS disorders has been if immense interest, with implications for undelrying pathophysiology.\u00a0 A variety of autoantibodies have been detected and associated with various CNS syndromes, although the question remians whether these antibodies are pathogenic, an epiphenomenon, or both. &nbsp; In this issue of JNNP, Hacohen and colleagues report on [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jnnp\/2014\/04\/10\/cns-antibodies-how-useful-are-they\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":160,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-362","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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