Factors influencing mortality in ALS are clearly multifactorial.\u00a0 The ability to determine these factors and subsequently modify them could be of therapeutic significance in ALS.\u00a0 The large EPIC cohort recently established that a higher body mass index may be neuroprotective, i.e. reduce mortality in ALS, which was evident in both males and females.\u00a0 This association could be explained by hypermetabolism.\u00a0 Namely ALS patients\u00a0 and SOD-1 mice seem to exhibit a hyper-metabolic state.\u00a0 Perhaps the link to sport may also have a similar etiology?\u00a0 Is this a chance association only?\u00a0 What do you think??<\/p>\n
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Gallo V et al. Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort. Neurology. 2013;80:829-838.<\/p>\n","protected":false},"excerpt":{"rendered":"
Factors influencing mortality in ALS are clearly multifactorial.\u00a0 The ability to determine these factors and subsequently modify them could be of therapeutic significance in ALS.\u00a0 The large EPIC cohort recently established that a higher body mass index may be neuroprotective, i.e. reduce mortality in ALS, which was evident in both males and females.\u00a0 This association […]<\/p>\n