Cortical atrophy, as assessed by novel volumetric MRI techniques, have revealed inconsistent results in ALS.\u00a0 Specifically, while cortical thinning, predominantly within the motor\/frontal lobe regions, have been reported by some, absence of atrophy has been reported by others.\u00a0 Mioshi and colleagues elegantly demonstrate a potential explanation for such discordant MRI findings.\u00a0 Namely, ALS patients with cognitive dysfunction exhibit abnormalities within the\u00a0motor and somatosensory areas\u00a0 while pure ALS patients have normal MRI findings.<\/p>\n
Could this be of diagnostic or event therapeutic significance in ALS?\u00a0 Perhaps!!<\/p>\n
Mioshi E, Lillo P, Yew B, Hsieh S, Savage S, Hodges JR, Kiernan MC, Hornberger M. Cortical atrophy in ALS is critically associated with neuropsychiatric and cognitive changes. Neurology. 2013 19;80:1117-23.<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Cortical atrophy, as assessed by novel volumetric MRI techniques, have revealed inconsistent results in ALS.\u00a0 Specifically, while cortical thinning, predominantly within the motor\/frontal lobe regions, have been reported by some, absence of atrophy has been reported by others.\u00a0 Mioshi and colleagues elegantly demonstrate a potential explanation for such discordant MRI findings.\u00a0 Namely, ALS patients with […]<\/p>\n