There are a number of risk factors that we commonly associate with stroke, including hypertension, smoking history, and diabetes. The current issue of JNNP explores the role of stress resilience in the aetiology of stroke http://jnnp.bmj.com/content/85/12/1331.abstract . The authors have assessed a large Swedish male population and have provided interesting insights into the role of […]
Month: November 2014
Working ok with CMT?
The issue of whether excessive work may lead to increased weakness in hereditary neuropathy is a vexing one and critical for patient management. in this issue of JNNP this notion has been categorcially dismissed. There was no worsening weakness with overwork in a large CMT1A cohort. Read more: http://jnnp.bmj.com/content/85/12/1354.abstract Neurol Neurosurg Psychiatry 2014;85:1354-1358 […]
Multiple sclerosis: what is the role of iron?
In the last decade or so, we have seen numerous major advances in our understanding of multiple sclerosis (MS). While the condition was traditionally viewed as a disease of the brain white matter, this hypothesis has been turned on its head with the discovery that grey matter involvement occurs in MS. Furthermore, we now know […]
ALS: A long pre-clinical period. Does it start at conception?
ALS is a rapidly progressive neurodegenerative disorder of the motor neurons with median survival of 3-5 years. The site of disease onset, and the timing of disease onset remain controversial, although a sudden and catastrophic degeneration of the motor neurons does occur. In this issue of JNNP a though provoking review by Eisen and colleagues […]