Ismail and colleagues report on a high concurrence rate of multiple sclerosis (MS) and ALS. Interestingly, the C9orf72 expansion was identified in 80% of the ALS-MS patients. Given that the inflammatory system appears to be deregulated in patients expressing the c9orf72 expansion, with down-regulation of the neuroprotective CXCL10 chemokine and dysfunction of NF-kB activity, the […]
Month: February 2013
When chocolate does not taste sweet!
Omar and colleagues identified abnormalities in processing and identification of common flavors in patients with frontotemporal lobe syndromes. This loss of flavor processing was associated with atrophy of the left entorhinal cortex, hippocampus, parahippocampal gyrus and temporal pole. From a clinical perspective, these findings provide insights into abnormal eating behavior patterns in FTD and ultimately […]