{"id":98,"date":"2011-01-30T03:25:51","date_gmt":"2011-01-30T03:25:51","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=98"},"modified":"2026-02-22T00:41:46","modified_gmt":"2026-02-22T00:41:46","slug":"a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2011\/01\/30\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations\/","title":{"rendered":"A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype\u2013phenotype correlations (Contributed by Dr. Saba Sharif)"},"content":{"rendered":"<p>Neurofibromatosis type 1 (NF1) is a common genetic disorder affecting 1 in 2500 individuals. Many individuals are mildly affected but a third of affected individuals unfortunately may develop one or more of the serious complications in their lifetime. One such complication is a benign tumour of the nerve to the eye (optic pathway glioma (OPG)) seen in 15% of\u00a0 children on scans but only 5-6% get symptoms. There is no way to predict who will develop an OPG and how they will be affected. This study has identified that individuals with OPGs are more likely to have changes in a specific region of the NF1 gene and this is something which may allow a simpler method of detection. Further studies are now needed to confirm this finding and also to see whether we can further predict the nature of the OPG by the specific gene change. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2011\/01\/28\/jmg.2010.081760?papetoc\">http:\/\/jmg.bmj.com\/content\/early\/2011\/01\/28\/jmg.2010.081760?papetoc<\/a>=)<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neurofibromatosis type 1 (NF1) is a common genetic disorder affecting 1 in 2500 individuals. Many individuals are mildly affected but a third of affected individuals unfortunately may develop one or more of the serious complications in their lifetime. One such complication is a benign tumour of the nerve to the eye (optic pathway glioma (OPG)) [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2011\/01\/30\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-98","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype\u2013phenotype correlations (Contributed by Dr. Saba Sharif) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2011\/01\/30\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype\u2013phenotype-correlations\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype\u2013phenotype correlations (Contributed by Dr. Saba Sharif) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Neurofibromatosis type 1 (NF1) is a common genetic disorder affecting 1 in 2500 individuals. Many individuals are mildly affected but a third of affected individuals unfortunately may develop one or more of the serious complications in their lifetime. One such complication is a benign tumour of the nerve to the eye (optic pathway glioma (OPG)) [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2011\/01\/30\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype\u2013phenotype-correlations\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2011-01-30T03:25:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-22T00:41:46+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/01\\\/30\\\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/01\\\/30\\\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype\u2013phenotype correlations (Contributed by Dr. Saba Sharif)\",\"datePublished\":\"2011-01-30T03:25:51+00:00\",\"dateModified\":\"2026-02-22T00:41:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/01\\\/30\\\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations\\\/\"},\"wordCount\":176,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/01\\\/30\\\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/01\\\/30\\\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/01\\\/30\\\/a-molecular-analysis-of-individuals-with-neurofibromatosis-type-1-nf1-and-optic-pathway-gliomas-opgs-and-an-assessment-of-genotype%e2%80%93phenotype-correlations\\\/\",\"name\":\"A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype\u2013phenotype correlations (Contributed by Dr. Saba Sharif) - 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