{"id":923,"date":"2016-09-14T18:59:33","date_gmt":"2016-09-14T18:59:33","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=923"},"modified":"2026-02-24T21:21:25","modified_gmt":"2026-02-24T21:21:25","slug":"carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/","title":{"rendered":"Carriers of a VEGFA enhancer polymorphism selectively binding CHOP\/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone (Contributed by Dr. Louise Torp Dalgaard)"},"content":{"rendered":"<p>Genetic variants (SNPs) in the vascular endothelial growth factor A (<em>VEGFA<\/em>) gene are associated with TSH levels. To characterize this association, we searched for SNPs in more than 8000 Danes. We identified rs881858 (in regulatory <em>enhancer<\/em> region of <em>VEGFA<\/em>), highly associated with human circulating TSH, which had alleles (A\/G) with differential binding to CHOP (C\/EBP homology protein) and C\/EBP\u03b2 (ccaat enhancer binding protein \u03b2) proteins.<\/p>\n<p>VEGF is an important angiogenic signal required for tissue expansion and is highly expressed in thyroid tissue. CHOP is a protein induced by cellular stress and these findings suggest a (genetically determined) stress-dependent response in normal or pathophysiological TSH stimulation of the thyroid. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2016\/09\/14\/jmedgenet-2016-104084\">http:\/\/jmg.bmj.com\/content\/early\/2016\/09\/14\/jmedgenet-2016-104084<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/files\/2016\/09\/Untitled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-924\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2016\/09\/Untitled-300x179.jpg\" alt=\"untitled\" width=\"300\" height=\"179\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2016\/09\/Untitled-300x179.jpg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2016\/09\/Untitled.jpg 360w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genetic variants (SNPs) in the vascular endothelial growth factor A (VEGFA) gene are associated with TSH levels. To characterize this association, we searched for SNPs in more than 8000 Danes. We identified rs881858 (in regulatory enhancer region of VEGFA), highly associated with human circulating TSH, which had alleles (A\/G) with differential binding to CHOP (C\/EBP [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-923","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Carriers of a VEGFA enhancer polymorphism selectively binding CHOP\/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone (Contributed by Dr. Louise Torp Dalgaard) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Carriers of a VEGFA enhancer polymorphism selectively binding CHOP\/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone (Contributed by Dr. Louise Torp Dalgaard) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Genetic variants (SNPs) in the vascular endothelial growth factor A (VEGFA) gene are associated with TSH levels. To characterize this association, we searched for SNPs in more than 8000 Danes. We identified rs881858 (in regulatory enhancer region of VEGFA), highly associated with human circulating TSH, which had alleles (A\/G) with differential binding to CHOP (C\/EBP [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2016-09-14T18:59:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T21:21:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2016\/09\/Untitled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"360\" \/>\n\t<meta property=\"og:image:height\" content=\"215\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/09\\\/14\\\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/09\\\/14\\\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Carriers of a VEGFA enhancer polymorphism selectively binding CHOP\\\/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone (Contributed by Dr. Louise Torp Dalgaard)\",\"datePublished\":\"2016-09-14T18:59:33+00:00\",\"dateModified\":\"2026-02-24T21:21:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/09\\\/14\\\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\\\/\"},\"wordCount\":142,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/09\\\/14\\\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2016\\\/09\\\/Untitled-300x179.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/09\\\/14\\\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/09\\\/14\\\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/09\\\/14\\\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\\\/\",\"name\":\"Carriers of a VEGFA enhancer polymorphism selectively binding CHOP\\\/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone (Contributed by Dr. Louise Torp Dalgaard) - 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We identified rs881858 (in regulatory enhancer region of VEGFA), highly associated with human circulating TSH, which had alleles (A\/G) with differential binding to CHOP (C\/EBP [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/","og_site_name":"JMG Contact blog","article_published_time":"2016-09-14T18:59:33+00:00","article_modified_time":"2026-02-24T21:21:25+00:00","og_image":[{"width":360,"height":215,"url":"https:\/\/blogs.bmj.com\/jmg\/files\/2016\/09\/Untitled.jpg","type":"image\/jpeg"}],"author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Carriers of a VEGFA enhancer polymorphism selectively binding CHOP\/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone (Contributed by Dr. Louise Torp Dalgaard)","datePublished":"2016-09-14T18:59:33+00:00","dateModified":"2026-02-24T21:21:25+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/"},"wordCount":142,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2016\/09\/Untitled-300x179.jpg","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/","url":"https:\/\/blogs.bmj.com\/jmg\/2016\/09\/14\/carriers-of-a-vegfa-enhancer-polymorphism-selectively-binding-chopddit3-are-predisposed-to-increased-circulating-levels-of-thyroid-stimulating-hormone\/","name":"Carriers of a VEGFA enhancer polymorphism selectively binding CHOP\/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone (Contributed by Dr. Louise Torp Dalgaard) - 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