{"id":916,"date":"2016-08-23T00:30:10","date_gmt":"2016-08-23T00:30:10","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=916"},"modified":"2026-02-24T21:22:49","modified_gmt":"2026-02-24T21:22:49","slug":"congenital-heart-defects-and-left-ventricular-non-compaction-in-males-with-loss-of-function-variants-in-nono","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2016\/08\/23\/congenital-heart-defects-and-left-ventricular-non-compaction-in-males-with-loss-of-function-variants-in-nono\/","title":{"rendered":"Congenital heart defects and left ventricular non-compaction in males with loss-of-function variants in NONO (Contributed by Dr. Daryl A. Scott)"},"content":{"rendered":"<p>Changes in an X chromosome gene called <em>NONO<\/em> have been shown to cause delayed development and intellectual disability in males.\u00a0 In this article we describe three males with changes in NONO who have the delayed development and intellectual disability previously described but also have heart defects and\/or abnormal heart muscles.\u00a0 This suggest that changes in <em>NONO<\/em> may put males at risk for developing heart problems.\u00a0\u00a0 We also found that males with changes in <em>NONO<\/em> often have large heads and sometime have changes in the nerve fibers that connect the right and left sides of the brain. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2016\/08\/22\/jmedgenet-2016-104039\">http:\/\/jmg.bmj.com\/content\/early\/2016\/08\/22\/jmedgenet-2016-104039<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Changes in an X chromosome gene called NONO have been shown to cause delayed development and intellectual disability in males.\u00a0 In this article we describe three males with changes in NONO who have the delayed development and intellectual disability previously described but also have heart defects and\/or abnormal heart muscles.\u00a0 This suggest that changes in [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2016\/08\/23\/congenital-heart-defects-and-left-ventricular-non-compaction-in-males-with-loss-of-function-variants-in-nono\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-916","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Congenital heart defects and left ventricular non-compaction in males with loss-of-function variants in NONO (Contributed by Dr. Daryl A. Scott) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2016\/08\/23\/congenital-heart-defects-and-left-ventricular-non-compaction-in-males-with-loss-of-function-variants-in-nono\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Congenital heart defects and left ventricular non-compaction in males with loss-of-function variants in NONO (Contributed by Dr. Daryl A. Scott) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Changes in an X chromosome gene called NONO have been shown to cause delayed development and intellectual disability in males.\u00a0 In this article we describe three males with changes in NONO who have the delayed development and intellectual disability previously described but also have heart defects and\/or abnormal heart muscles.\u00a0 This suggest that changes in [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2016\/08\/23\/congenital-heart-defects-and-left-ventricular-non-compaction-in-males-with-loss-of-function-variants-in-nono\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2016-08-23T00:30:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T21:22:49+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/08\\\/23\\\/congenital-heart-defects-and-left-ventricular-non-compaction-in-males-with-loss-of-function-variants-in-nono\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/08\\\/23\\\/congenital-heart-defects-and-left-ventricular-non-compaction-in-males-with-loss-of-function-variants-in-nono\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Congenital heart defects and left ventricular non-compaction in males with loss-of-function variants in NONO (Contributed by Dr. Daryl A. 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