{"id":880,"date":"2016-04-11T18:58:01","date_gmt":"2016-04-11T18:58:01","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=880"},"modified":"2026-02-25T00:10:39","modified_gmt":"2026-02-25T00:10:39","slug":"functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2016\/04\/11\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\/","title":{"rendered":"Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population (Contributed by Marie Aare Vestmar)"},"content":{"rendered":"<p>The 7TM receptor for long chain fatty acids FFAR4 (GPR120) currently attracts great attention as a therapeutic target to treat metabolic diseases. A low-frequency missense variant (p.R270H, rs116454156) in FFAR4 has previously been reported to associate with obesity in European populations and to impair signaling of the receptor. Here we further examine the functional consequences of p.R270H on receptor properties, and expand the human association studies by investigating traits of relevance for obesity- and glucose metabolism. Despite impaired effects on receptor function, we found no statistically significant associations with any examined traits. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2016\/04\/11\/jmedgenet-2015-103728\">http:\/\/jmg.bmj.com\/content\/early\/2016\/04\/11\/jmedgenet-2015-103728<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The 7TM receptor for long chain fatty acids FFAR4 (GPR120) currently attracts great attention as a therapeutic target to treat metabolic diseases. A low-frequency missense variant (p.R270H, rs116454156) in FFAR4 has previously been reported to associate with obesity in European populations and to impair signaling of the receptor. Here we further examine the functional consequences [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2016\/04\/11\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-880","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population (Contributed by Marie Aare Vestmar) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2016\/04\/11\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population (Contributed by Marie Aare Vestmar) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"The 7TM receptor for long chain fatty acids FFAR4 (GPR120) currently attracts great attention as a therapeutic target to treat metabolic diseases. A low-frequency missense variant (p.R270H, rs116454156) in FFAR4 has previously been reported to associate with obesity in European populations and to impair signaling of the receptor. Here we further examine the functional consequences [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2016\/04\/11\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2016-04-11T18:58:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T00:10:39+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/04\\\/11\\\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/04\\\/11\\\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population (Contributed by Marie Aare Vestmar)\",\"datePublished\":\"2016-04-11T18:58:01+00:00\",\"dateModified\":\"2026-02-25T00:10:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/04\\\/11\\\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\\\/\"},\"wordCount\":126,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/04\\\/11\\\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/04\\\/11\\\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2016\\\/04\\\/11\\\/functional-and-genetic-epidemiological-characterisation-of-the-ffar4-gpr120-p-r270h-variant-in-the-danish-population\\\/\",\"name\":\"Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population (Contributed by Marie Aare Vestmar) - 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