{"id":828,"date":"2015-11-26T17:51:19","date_gmt":"2015-11-26T17:51:19","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=828"},"modified":"2026-02-25T00:33:56","modified_gmt":"2026-02-25T00:33:56","slug":"intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/","title":{"rendered":"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries)"},"content":{"rendered":"<p>Tuberous sclerosis complex (TSC) is a genetic disorder with a birth incidence of 1 in 6000, which is quite common for a \u2018rare\u2019 genetic disease. The two genes, their proteins and intracellular signalling pathways have been identified. TSC leads to multi-system involvement including benign tumours and very high rates of TSC-associated neuropsychiatric disorders. Some people with TSC have severe to profound intellectual disability, while others are intellectually very able. This paper reports correlations between particular kinds of mutations and the level of intellectual ability, opening the way for detailed biochemical testing of the proposed effects of TSC mutations on intellectual development and intellectual developmental disability. (<a href=\"http:\/\/jmg.bmj.com\/content\/52\/12\/815\">http:\/\/jmg.bmj.com\/content\/52\/12\/815<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-829\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus-254x300.jpg\" alt=\"ProfPetrus\" width=\"254\" height=\"300\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus-254x300.jpg 254w, https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus.jpg 409w\" sizes=\"auto, (max-width: 254px) 100vw, 254px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tuberous sclerosis complex (TSC) is a genetic disorder with a birth incidence of 1 in 6000, which is quite common for a \u2018rare\u2019 genetic disease. The two genes, their proteins and intracellular signalling pathways have been identified. TSC leads to multi-system involvement including benign tumours and very high rates of TSC-associated neuropsychiatric disorders. Some people [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-828","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Tuberous sclerosis complex (TSC) is a genetic disorder with a birth incidence of 1 in 6000, which is quite common for a \u2018rare\u2019 genetic disease. The two genes, their proteins and intracellular signalling pathways have been identified. TSC leads to multi-system involvement including benign tumours and very high rates of TSC-associated neuropsychiatric disorders. Some people [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2015-11-26T17:51:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T00:33:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"409\" \/>\n\t<meta property=\"og:image:height\" content=\"483\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries)\",\"datePublished\":\"2015-11-26T17:51:19+00:00\",\"dateModified\":\"2026-02-25T00:33:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/\"},\"wordCount\":132,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2015\\\/11\\\/ProfPetrus-254x300.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/\",\"name\":\"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2015\\\/11\\\/ProfPetrus-254x300.jpg\",\"datePublished\":\"2015-11-26T17:51:19+00:00\",\"dateModified\":\"2026-02-25T00:33:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/#primaryimage\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2015\\\/11\\\/ProfPetrus.jpg\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2015\\\/11\\\/ProfPetrus.jpg\",\"width\":409,\"height\":483},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/26\\\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/","og_locale":"en_US","og_type":"article","og_title":"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries) - JMG Contact blog","og_description":"Tuberous sclerosis complex (TSC) is a genetic disorder with a birth incidence of 1 in 6000, which is quite common for a \u2018rare\u2019 genetic disease. The two genes, their proteins and intracellular signalling pathways have been identified. TSC leads to multi-system involvement including benign tumours and very high rates of TSC-associated neuropsychiatric disorders. Some people [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/","og_site_name":"JMG Contact blog","article_published_time":"2015-11-26T17:51:19+00:00","article_modified_time":"2026-02-25T00:33:56+00:00","og_image":[{"width":409,"height":483,"url":"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus.jpg","type":"image\/jpeg"}],"author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries)","datePublished":"2015-11-26T17:51:19+00:00","dateModified":"2026-02-25T00:33:56+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/"},"wordCount":132,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus-254x300.jpg","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/","url":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/","name":"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"primaryImageOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/#primaryimage"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus-254x300.jpg","datePublished":"2015-11-26T17:51:19+00:00","dateModified":"2026-02-25T00:33:56+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/#primaryimage","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus.jpg","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2015\/11\/ProfPetrus.jpg","width":409,"height":483},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/26\/intellectual-ability-in-tuberous-sclerosis-complex-correlates-with-predicted-effects-of-mutations-on-tsc1-and-tsc2-proteins\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"Intellectual ability in tuberous sclerosis complex correlates with predicted effects of mutations on TSC1 and TSC2 proteins (Contributed by Prof Petrus J de Vries)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=828"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/828\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}