{"id":820,"date":"2015-11-03T19:18:32","date_gmt":"2015-11-03T19:18:32","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=820"},"modified":"2026-02-25T00:36:04","modified_gmt":"2026-02-25T00:36:04","slug":"targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/03\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\/","title":{"rendered":"Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families (Contributed by Dr. Georgia Chenevix-Trench)"},"content":{"rendered":"<p>The authors performed specific sequencing 17 known and putative breast cancer susceptibility genes in 660 women with familial breast cancer who did not carry a mutation the known susceptibility genes, BRCA1 or BRCA2. The authors then evaluated the putative cancer-related mutations and found in relevant family members to determine whether they were carried by affected family members. Only variants in the CDH1, CHEK2, PALB2 and TP53 genes showed evidence of a significantly increased risk of breast cancer, with some supportive evidence that mutations in ATM confer moderate risk. The authors found that panel testing for these breast cancer families provided additional relevant clinical information for &lt;2% of families. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2015\/11\/03\/jmedgenet-2015-103452\">http:\/\/jmg.bmj.com\/content\/early\/2015\/11\/03\/jmedgenet-2015-103452<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The authors performed specific sequencing 17 known and putative breast cancer susceptibility genes in 660 women with familial breast cancer who did not carry a mutation the known susceptibility genes, BRCA1 or BRCA2. The authors then evaluated the putative cancer-related mutations and found in relevant family members to determine whether they were carried by affected [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/03\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-820","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families (Contributed by Dr. Georgia Chenevix-Trench) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/03\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families (Contributed by Dr. Georgia Chenevix-Trench) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"The authors performed specific sequencing 17 known and putative breast cancer susceptibility genes in 660 women with familial breast cancer who did not carry a mutation the known susceptibility genes, BRCA1 or BRCA2. The authors then evaluated the putative cancer-related mutations and found in relevant family members to determine whether they were carried by affected [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2015\/11\/03\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2015-11-03T19:18:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T00:36:04+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/03\\\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/03\\\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families (Contributed by Dr. Georgia Chenevix-Trench)\",\"datePublished\":\"2015-11-03T19:18:32+00:00\",\"dateModified\":\"2026-02-25T00:36:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/03\\\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\\\/\"},\"wordCount\":143,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/03\\\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/03\\\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/11\\\/03\\\/targeted-massively-parallel-sequencing-of-a-panel-of-putative-breast-cancer-susceptibility-genes-in-a-large-cohort-of-multiple-case-breast-and-ovarian-cancer-families\\\/\",\"name\":\"Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families (Contributed by Dr. Georgia Chenevix-Trench) - 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