{"id":750,"date":"2015-04-23T22:46:45","date_gmt":"2015-04-23T22:46:45","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=750"},"modified":"2026-02-25T01:08:12","modified_gmt":"2026-02-25T01:08:12","slug":"prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2015\/04\/23\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\/","title":{"rendered":"Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer (Contributed by Dr. Jos\u00e9 Luis Soto)"},"content":{"rendered":"<p>Lynch syndrome is a hereditary condition which predispose to colorectal cancer and other tumors. A particular cause of this syndrome is the <em>MLH1<\/em> constitutional methylation (epimutation). Universal tumor testing is recommended as the best strategy to identify Lynch syndrome patients. This screening renders a considerable number of cases with <em>MLH1<\/em> methylation in tumors raising the question to test or not, for constitutional epimutation. Our results suggest that the prevalence of constitutional epimutation is negligible in colorectal cancer patients who do not fulfil the risk criteria, rendering this testing unnecessary in members of the general population who lack cancer history or are aged at the time of diagnosis. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2015\/04\/23\/jmedgenet-2015-103076\">http:\/\/jmg.bmj.com\/content\/early\/2015\/04\/23\/jmedgenet-2015-103076<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lynch syndrome is a hereditary condition which predispose to colorectal cancer and other tumors. A particular cause of this syndrome is the MLH1 constitutional methylation (epimutation). Universal tumor testing is recommended as the best strategy to identify Lynch syndrome patients. This screening renders a considerable number of cases with MLH1 methylation in tumors raising the [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2015\/04\/23\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-750","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer (Contributed by Dr. Jos\u00e9 Luis Soto) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2015\/04\/23\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer (Contributed by Dr. Jos\u00e9 Luis Soto) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Lynch syndrome is a hereditary condition which predispose to colorectal cancer and other tumors. A particular cause of this syndrome is the MLH1 constitutional methylation (epimutation). Universal tumor testing is recommended as the best strategy to identify Lynch syndrome patients. This screening renders a considerable number of cases with MLH1 methylation in tumors raising the [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2015\/04\/23\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2015-04-23T22:46:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T01:08:12+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/04\\\/23\\\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/04\\\/23\\\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer (Contributed by Dr. Jos\u00e9 Luis Soto)\",\"datePublished\":\"2015-04-23T22:46:45+00:00\",\"dateModified\":\"2026-02-25T01:08:12+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/04\\\/23\\\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\\\/\"},\"wordCount\":143,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/04\\\/23\\\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/04\\\/23\\\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2015\\\/04\\\/23\\\/prevalence-of-mlh1-constitutional-epimutations-as-a-cause-of-lynch-syndrome-in-unselected-versus-selected-consecutive-series-of-patients-with-colorectal-cancer\\\/\",\"name\":\"Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer (Contributed by Dr. Jos\u00e9 Luis Soto) - 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