{"id":714,"date":"2014-12-24T02:54:28","date_gmt":"2014-12-24T02:54:28","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=714"},"modified":"2026-02-25T19:32:50","modified_gmt":"2026-02-25T19:32:50","slug":"novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/24\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\/","title":{"rendered":"Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells (Contributed by Dr. Songbin Fu)"},"content":{"rendered":"<p>Gene amplification plays an important role in tumor progression and development of drug resistance, which manifested cytogenetically as double minutes (DMs) or homogeneously staining regions (HSRs). To better understand the molecular mechanism by which HSRs and DMs are formed and how they relate to the development of methotrexate (MTX) resistance, two model systems harboring HSRs and DMs were used, respectively. In this study, we, for the first time, demonstrate a novel specific role for NHEJ in the formation of DMs, but not HSRs, in MTX-resistant cells, and that NHEJ might be a potential target for the treatment of MTX-resistant colon cancer. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2014\/12\/23\/jmedgenet-2014-102703\">http:\/\/jmg.bmj.com\/content\/early\/2014\/12\/23\/jmedgenet-2014-102703<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/picture.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-716\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/picture-300x150.jpg\" alt=\"?????\" width=\"300\" height=\"150\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/picture-300x150.jpg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/picture-1024x513.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gene amplification plays an important role in tumor progression and development of drug resistance, which manifested cytogenetically as double minutes (DMs) or homogeneously staining regions (HSRs). To better understand the molecular mechanism by which HSRs and DMs are formed and how they relate to the development of methotrexate (MTX) resistance, two model systems harboring HSRs [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/24\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-714","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells (Contributed by Dr. Songbin Fu) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/24\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells (Contributed by Dr. Songbin Fu) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Gene amplification plays an important role in tumor progression and development of drug resistance, which manifested cytogenetically as double minutes (DMs) or homogeneously staining regions (HSRs). To better understand the molecular mechanism by which HSRs and DMs are formed and how they relate to the development of methotrexate (MTX) resistance, two model systems harboring HSRs [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/24\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-12-24T02:54:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T19:32:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/picture.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2114\" \/>\n\t<meta property=\"og:image:height\" content=\"1059\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/24\\\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/24\\\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells (Contributed by Dr. Songbin Fu)\",\"datePublished\":\"2014-12-24T02:54:28+00:00\",\"dateModified\":\"2026-02-25T19:32:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/24\\\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\\\/\"},\"wordCount\":131,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/24\\\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2014\\\/12\\\/picture-300x150.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/24\\\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/24\\\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/24\\\/novel-role-for-non-homologous-end-joining-in-the-formation-of-double-minutes-in-methotrexate-resistant-colon-cancer-cells\\\/\",\"name\":\"Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells (Contributed by Dr. Songbin Fu) - 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