{"id":709,"date":"2014-12-17T01:43:12","date_gmt":"2014-12-17T01:43:12","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=709"},"modified":"2026-02-25T19:33:58","modified_gmt":"2026-02-25T19:33:58","slug":"mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/17\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\/","title":{"rendered":"Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis (Contributed by Dr. Brian Z Ring)"},"content":{"rendered":"<p>Pediatric hearing loss is a common disorder and universal newborn hearing screening is used to aid in the early identification of children with hearing impairment. However this screening has a significant failure rate in newborns, and hearing loss may have delayed onset and be missed by newborn screening. Genetic screening of newborns for variants that may predispose towards nonsyndromic hearing loss is being increasingly explored as a means to supplement standard audiologic examinations. Here we examined the association of mitochondrial mutations with non-syndromic hearing loss in previously published studies, including the effect of ethnicity, audiologic test methods and aminoglycoside exposure. This analysis identified several mitochondrial variants that were significantly associated with hearing loss susceptibility. Mutations that are significant when exposure to aminoglycoside is considered were also identified. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2014\/12\/16\/jmedgenet-2014-102753\">http:\/\/jmg.bmj.com\/content\/early\/2014\/12\/16\/jmedgenet-2014-102753<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/DPP0011.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-710\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/DPP0011-300x290.jpg\" alt=\"DPP0011\" width=\"300\" height=\"290\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/DPP0011-300x290.jpg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/DPP0011-1024x990.jpg 1024w, https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/DPP0011.jpg 1852w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pediatric hearing loss is a common disorder and universal newborn hearing screening is used to aid in the early identification of children with hearing impairment. However this screening has a significant failure rate in newborns, and hearing loss may have delayed onset and be missed by newborn screening. Genetic screening of newborns for variants that [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/17\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-709","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis (Contributed by Dr. Brian Z Ring) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/17\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis (Contributed by Dr. Brian Z Ring) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Pediatric hearing loss is a common disorder and universal newborn hearing screening is used to aid in the early identification of children with hearing impairment. However this screening has a significant failure rate in newborns, and hearing loss may have delayed onset and be missed by newborn screening. Genetic screening of newborns for variants that [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/17\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-12-17T01:43:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T19:33:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/12\/DPP0011-1024x990.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"990\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/17\\\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/17\\\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis (Contributed by Dr. Brian Z Ring)\",\"datePublished\":\"2014-12-17T01:43:12+00:00\",\"dateModified\":\"2026-02-25T19:33:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/17\\\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\\\/\"},\"wordCount\":154,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/17\\\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2014\\\/12\\\/DPP0011-300x290.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/17\\\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/17\\\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/12\\\/17\\\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\\\/\",\"name\":\"Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis (Contributed by Dr. Brian Z Ring) - 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His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis (Contributed by Dr. Brian Z Ring) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2014\/12\/17\/mitochondrial-mutations-associated-with-aminoglycoside-ototoxicity-and-hearing-loss-susceptibility-identified-by-meta-analysis\/","og_locale":"en_US","og_type":"article","og_title":"Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis (Contributed by Dr. Brian Z Ring) - JMG Contact blog","og_description":"Pediatric hearing loss is a common disorder and universal newborn hearing screening is used to aid in the early identification of children with hearing impairment. 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