{"id":670,"date":"2014-08-05T18:28:52","date_gmt":"2014-08-05T18:28:52","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=670"},"modified":"2026-02-25T19:42:30","modified_gmt":"2026-02-25T19:42:30","slug":"comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2014\/08\/05\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\/","title":{"rendered":"Comprehensive genotype phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation (Contributed by Ngoc Minh Phuong Nguyen)"},"content":{"rendered":"<p>Hydatidiform mole (HM) is a human pregnancy with no embryo, but excessive trophoblastic proliferation. Maternal recessive mutationsin <em>NLRP7<\/em> are responsible for recurrent HMs, which are characterized by diploid biparental genomes, abnormal DNA methylation, and absence of p57<sup>Kip2<\/sup> expression, the protein coded by the imprinted<em> CDKN1C<\/em> gene. In this study, we demonstrate a strong correlation between the nature of <em>NLRP7<\/em> mutations in the patients and the phenotypical features of their HMs. Protein-truncating mutations repress p57<sup>KIP2<\/sup> expression and are associated with the absence of embryonic tissues and excessive trophoblastic proliferation. However, some missense mutations do not completely repress p57<sup>KIP2<\/sup> expression and are associated with the presence of embryonic tissues and mild trophoblastic proliferation. Our data suggest a novel role for NLRP7in regulating the balance between tissue differentiation and proliferation during early development. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2014\/08\/05\/jmedgenet-2014-102546\">http:\/\/jmg.bmj.com\/content\/early\/2014\/08\/05\/jmedgenet-2014-102546<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hydatidiform mole (HM) is a human pregnancy with no embryo, but excessive trophoblastic proliferation. Maternal recessive mutationsin NLRP7 are responsible for recurrent HMs, which are characterized by diploid biparental genomes, abnormal DNA methylation, and absence of p57Kip2 expression, the protein coded by the imprinted CDKN1C gene. In this study, we demonstrate a strong correlation between [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/08\/05\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-670","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Comprehensive genotype phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation (Contributed by Ngoc Minh Phuong Nguyen) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/08\/05\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comprehensive genotype phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation (Contributed by Ngoc Minh Phuong Nguyen) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Hydatidiform mole (HM) is a human pregnancy with no embryo, but excessive trophoblastic proliferation. Maternal recessive mutationsin NLRP7 are responsible for recurrent HMs, which are characterized by diploid biparental genomes, abnormal DNA methylation, and absence of p57Kip2 expression, the protein coded by the imprinted CDKN1C gene. In this study, we demonstrate a strong correlation between [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2014\/08\/05\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-08-05T18:28:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T19:42:30+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/08\\\/05\\\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/08\\\/05\\\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Comprehensive genotype phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation (Contributed by Ngoc Minh Phuong Nguyen)\",\"datePublished\":\"2014-08-05T18:28:52+00:00\",\"dateModified\":\"2026-02-25T19:42:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/08\\\/05\\\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\\\/\"},\"wordCount\":166,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/08\\\/05\\\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/08\\\/05\\\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/08\\\/05\\\/comprehensive-genotype-phenotype-correlations-between-nlrp7-mutations-and-the-balance-between-embryonic-tissue-differentiation-and-trophoblastic-proliferation\\\/\",\"name\":\"Comprehensive genotype phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation (Contributed by Ngoc Minh Phuong Nguyen) - 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