{"id":665,"date":"2014-07-25T19:35:59","date_gmt":"2014-07-25T19:35:59","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=665"},"modified":"2026-02-25T19:43:56","modified_gmt":"2026-02-25T19:43:56","slug":"human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2014\/07\/25\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\/","title":{"rendered":"Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research (Contributed by Dr Richard Saffery)"},"content":{"rendered":"

This Position Paper draws together the emerging evidence that the early life experience of parents and\/or ancestors can influence development and common disease risk in the current generation, with the aim of promoting human transgenerational research . The few human observational studies reported to date of the effects of ancestral exposures (such as nutrition or smoking) support transgenerational effects that cannot easily be attributed to cultural and\/or genetic inheritance. This points to non-genetic biological inheritance in humans similar to that convincingly demonstrated in transgenerational animal experiments, particularly involving altered nutritional or stress exposures. The authors argue that transgenerational responses to specific exposures in previous generations should be factored into future studies with a public health focus. (http:\/\/jmg.bmj.com\/content\/early\/2014\/07\/25\/jmedgenet-2014-102577<\/a> )<\/p>\n

\"Photo<\/a><\/p>\n

Harvest in northern Sweden a hundred years ago <\/strong>(\u00a9 the Demographic Database, Ume\u00e5 University)
\n<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

This Position Paper draws together the emerging evidence that the early life experience of parents and\/or ancestors can influence development and common disease risk in the current generation, with the aim of promoting human transgenerational research . The few human observational studies reported to date of the effects of ancestral exposures (such as nutrition or […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-665","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nHuman transgenerational responses to early-life experience: potential impact on development, health and biomedical research (Contributed by Dr Richard Saffery) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/07\/25\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research (Contributed by Dr Richard Saffery) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"This Position Paper draws together the emerging evidence that the early life experience of parents and\/or ancestors can influence development and common disease risk in the current generation, with the aim of promoting human transgenerational research . The few human observational studies reported to date of the effects of ancestral exposures (such as nutrition or [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2014\/07\/25\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-07-25T19:35:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T19:43:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/07\/Photo-for-Pembrey-et-al-JMG-blog-July-2014.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1877\" \/>\n\t<meta property=\"og:image:height\" content=\"1370\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/25\\\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/25\\\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research (Contributed by Dr Richard Saffery)\",\"datePublished\":\"2014-07-25T19:35:59+00:00\",\"dateModified\":\"2026-02-25T19:43:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/25\\\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\\\/\"},\"wordCount\":157,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/25\\\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2014\\\/07\\\/Photo-for-Pembrey-et-al-JMG-blog-July-2014-300x218.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/25\\\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/25\\\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/25\\\/human-transgenerational-responses-to-early-life-experience-potential-impact-on-development-health-and-biomedical-research\\\/\",\"name\":\"Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research (Contributed by Dr Richard Saffery) - 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