{"id":663,"date":"2014-07-23T18:35:33","date_gmt":"2014-07-23T18:35:33","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=663"},"modified":"2026-02-25T19:44:17","modified_gmt":"2026-02-25T19:44:17","slug":"meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2014\/07\/23\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\/","title":{"rendered":"Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance (Contributed by Dr. Yolande Ramos)"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/07\/TreatOA.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-664\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/07\/TreatOA-300x51.jpg\" alt=\"?????\" width=\"300\" height=\"51\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/07\/TreatOA-300x51.jpg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2014\/07\/TreatOA-1024x175.jpg 1024w, https:\/\/blogs.bmj.com\/jmg\/files\/2014\/07\/TreatOA.jpg 1585w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Prevalence of osteoarthritis (OA), a disabling disease of the joints, increases with age which is expected to become a major problem in health care given the growing elderly population and the poor treatment options. Research to apply potential biomarkers such as serum COMP or urinary CTX-II to monitor OA is promising. However, adequate discrimination between patients and controls is still limited which may be due to innate differences in biomarker levels hampering the association to OA disease status.<\/p>\n<p>By combining data from 7 European cohorts from the TreatOA consortium we identified genetic markers near <em>CSDM1 <\/em> and near <em>MRC1<\/em> and the <em>COMP<\/em> gene itself, affecting respectively uCTX-II and sCOMP levels.<\/p>\n<p>We advocate that increased biomarker performance for OA may be accomplished by taking such genetic variation into account. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2014\/07\/23\/jmedgenet-2014-102478\">http:\/\/jmg.bmj.com\/content\/early\/2014\/07\/23\/jmedgenet-2014-102478<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prevalence of osteoarthritis (OA), a disabling disease of the joints, increases with age which is expected to become a major problem in health care given the growing elderly population and the poor treatment options. Research to apply potential biomarkers such as serum COMP or urinary CTX-II to monitor OA is promising. However, adequate discrimination between [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/07\/23\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-663","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance (Contributed by Dr. Yolande Ramos) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/07\/23\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance (Contributed by Dr. Yolande Ramos) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Prevalence of osteoarthritis (OA), a disabling disease of the joints, increases with age which is expected to become a major problem in health care given the growing elderly population and the poor treatment options. Research to apply potential biomarkers such as serum COMP or urinary CTX-II to monitor OA is promising. However, adequate discrimination between [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2014\/07\/23\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-07-23T18:35:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T19:44:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2014\/07\/TreatOA.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1585\" \/>\n\t<meta property=\"og:image:height\" content=\"272\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/23\\\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/23\\\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance (Contributed by Dr. Yolande Ramos)\",\"datePublished\":\"2014-07-23T18:35:33+00:00\",\"dateModified\":\"2026-02-25T19:44:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/23\\\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\\\/\"},\"wordCount\":156,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/23\\\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2014\\\/07\\\/TreatOA-300x51.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/23\\\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/23\\\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/07\\\/23\\\/meta-analysis-identifies-loci-affecting-levels-of-the-potential-osteoarthritis-biomarkers-scomp-and-uctx-ii-with-genome-wide-significance\\\/\",\"name\":\"Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance (Contributed by Dr. Yolande Ramos) - 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