{"id":618,"date":"2014-01-08T20:25:12","date_gmt":"2014-01-08T20:25:12","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=618"},"modified":"2026-02-25T19:52:48","modified_gmt":"2026-02-25T19:52:48","slug":"prenylation-defects-in-inherited-retinal-diseases","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2014\/01\/08\/prenylation-defects-in-inherited-retinal-diseases\/","title":{"rendered":"Prenylation defects in inherited retinal diseases (Contributed by Dr. Anna Siemiatkowska)"},"content":{"rendered":"

To fulfil their specialised functions, retinal proteins are located at specific positions in photoreceptor cells. These cells consist of many different compartments. Proteins are transported between these compartments through their binding to other proteins or to membranous vesicles. To interact with other proteins or vesicles, proteins contain a hydrophobic lipid molecule, a prenyl group. Many proteins that are mutated in patients with inherited retinal diseases carry a prenyl group or are involved in the synthesis of the prenyl groups. In this review, we discuss the entire spectrum of prenylation defects underlying inherited retinal diseases and propose overlapping diseases mechanisms. (http:\/\/jmg.bmj.com\/content\/early\/2014\/01\/08\/jmedgenet-2013-102138<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

To fulfil their specialised functions, retinal proteins are located at specific positions in photoreceptor cells. These cells consist of many different compartments. Proteins are transported between these compartments through their binding to other proteins or to membranous vesicles. To interact with other proteins or vesicles, proteins contain a hydrophobic lipid molecule, a prenyl group. Many […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-618","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nPrenylation defects in inherited retinal diseases (Contributed by Dr. Anna Siemiatkowska) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2014\/01\/08\/prenylation-defects-in-inherited-retinal-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prenylation defects in inherited retinal diseases (Contributed by Dr. Anna Siemiatkowska) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"To fulfil their specialised functions, retinal proteins are located at specific positions in photoreceptor cells. These cells consist of many different compartments. Proteins are transported between these compartments through their binding to other proteins or to membranous vesicles. To interact with other proteins or vesicles, proteins contain a hydrophobic lipid molecule, a prenyl group. Many [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2014\/01\/08\/prenylation-defects-in-inherited-retinal-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-01-08T20:25:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T19:52:48+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/01\\\/08\\\/prenylation-defects-in-inherited-retinal-diseases\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/01\\\/08\\\/prenylation-defects-in-inherited-retinal-diseases\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Prenylation defects in inherited retinal diseases (Contributed by Dr. Anna Siemiatkowska)\",\"datePublished\":\"2014-01-08T20:25:12+00:00\",\"dateModified\":\"2026-02-25T19:52:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/01\\\/08\\\/prenylation-defects-in-inherited-retinal-diseases\\\/\"},\"wordCount\":118,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/01\\\/08\\\/prenylation-defects-in-inherited-retinal-diseases\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/01\\\/08\\\/prenylation-defects-in-inherited-retinal-diseases\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2014\\\/01\\\/08\\\/prenylation-defects-in-inherited-retinal-diseases\\\/\",\"name\":\"Prenylation defects in inherited retinal diseases (Contributed by Dr. Anna Siemiatkowska) - 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His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Prenylation defects in inherited retinal diseases (Contributed by Dr. Anna Siemiatkowska) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2014\/01\/08\/prenylation-defects-in-inherited-retinal-diseases\/","og_locale":"en_US","og_type":"article","og_title":"Prenylation defects in inherited retinal diseases (Contributed by Dr. Anna Siemiatkowska) - JMG Contact blog","og_description":"To fulfil their specialised functions, retinal proteins are located at specific positions in photoreceptor cells. 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