{"id":604,"date":"2013-12-16T20:19:50","date_gmt":"2013-12-16T20:19:50","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=604"},"modified":"2026-02-25T19:55:35","modified_gmt":"2026-02-25T19:55:35","slug":"autism-traits-in-the-rasopathies","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2013\/12\/16\/autism-traits-in-the-rasopathies\/","title":{"rendered":"Autism traits in the RASopathies (Contributed by Brigid Adviento)"},"content":{"rendered":"<p>This \u2018pathway\u2019 approach investigates the Ras\/MAPK signaling role in autism traits.\u00a0 A large sample representing genetic disorders (RASopathies) caused by mutations activating this pathway was compared with sibling controls and autism spectrum disorder (ASD) subjects.\u00a0 Each RASopathy (Neurofibromatosis type 1, Noonan syndrome, Costello syndrome, and cardio-facio-cutaneous syndrome) is associated with autism traits, with distinct distributions.\u00a0 Impairment across ASD domains and male autism bias in RASopathy subjects suggest similarities to ASDs.\u00a0 Individuals with RASopathies should be offered testing and treatment for social communication impairment. Future studies could explore modifying factors contributing to variation within RASopathies and Ras\/MAPK signaling in non-RASopathy ASDs. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2013\/10\/07\/jmedgenet-2013-101951\">http:\/\/jmg.bmj.com\/content\/early\/2013\/10\/07\/jmedgenet-2013-101951<\/a> )<a href=\"https:\/\/blogs.bmj.com\/jmg\/files\/2013\/12\/labphoto.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-605\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2013\/12\/labphoto-300x225.jpg\" alt=\"labphoto\" width=\"300\" height=\"225\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This \u2018pathway\u2019 approach investigates the Ras\/MAPK signaling role in autism traits.\u00a0 A large sample representing genetic disorders (RASopathies) caused by mutations activating this pathway was compared with sibling controls and autism spectrum disorder (ASD) subjects.\u00a0 Each RASopathy (Neurofibromatosis type 1, Noonan syndrome, Costello syndrome, and cardio-facio-cutaneous syndrome) is associated with autism traits, with distinct distributions.\u00a0 [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2013\/12\/16\/autism-traits-in-the-rasopathies\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-604","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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