{"id":570,"date":"2013-07-12T02:53:04","date_gmt":"2013-07-12T02:53:04","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=570"},"modified":"2026-02-25T20:01:47","modified_gmt":"2026-02-25T20:01:47","slug":"confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2013\/07\/12\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\/","title":{"rendered":"Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population (Contributed by Dr. Yu-Long Wang)"},"content":{"rendered":"<p>Four candidate loci, rs965513 (9q22.33), rs944289 (14q13.3), rs966423 (2q35) and rs2439302 (8p12), identified by genome-wide association studies (GWAS) for papillary thyroid cancer (PTC) risk in European population were confirmed in a Chinese population. rs944289 was also associated with an increased benign thyroid tumor risk. The PTC risk of carriers of risk alleles was shown to increase with accumulating number of risk alleles. Functional prediction by bioinformatic analysis showed that rs966423 (2q35) and rs2439302 (8p12) are located within CTCF binding regions, which may change the transcriptional regulation of DIRC3 and NRG1, respectively. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2013\/07\/10\/jmedgenet-2013-101687\">http:\/\/jmg.bmj.com\/content\/early\/2013\/07\/10\/jmedgenet-2013-101687<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Four candidate loci, rs965513 (9q22.33), rs944289 (14q13.3), rs966423 (2q35) and rs2439302 (8p12), identified by genome-wide association studies (GWAS) for papillary thyroid cancer (PTC) risk in European population were confirmed in a Chinese population. rs944289 was also associated with an increased benign thyroid tumor risk. The PTC risk of carriers of risk alleles was shown to [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2013\/07\/12\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-570","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population (Contributed by Dr. Yu-Long Wang) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2013\/07\/12\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population (Contributed by Dr. Yu-Long Wang) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Four candidate loci, rs965513 (9q22.33), rs944289 (14q13.3), rs966423 (2q35) and rs2439302 (8p12), identified by genome-wide association studies (GWAS) for papillary thyroid cancer (PTC) risk in European population were confirmed in a Chinese population. rs944289 was also associated with an increased benign thyroid tumor risk. The PTC risk of carriers of risk alleles was shown to [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2013\/07\/12\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2013-07-12T02:53:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T20:01:47+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/07\\\/12\\\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/07\\\/12\\\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population (Contributed by Dr. Yu-Long Wang)\",\"datePublished\":\"2013-07-12T02:53:04+00:00\",\"dateModified\":\"2026-02-25T20:01:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/07\\\/12\\\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\\\/\"},\"wordCount\":127,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/07\\\/12\\\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/07\\\/12\\\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/07\\\/12\\\/confirmation-of-papillary-thyroid-cancer-susceptibility-loci-identified-by-genome-wide-association-studies-of-chromosomes-14q13-9q22-2q35-and-8p12-in-a-chinese-population\\\/\",\"name\":\"Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population (Contributed by Dr. Yu-Long Wang) - 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