{"id":567,"date":"2013-07-12T02:50:47","date_gmt":"2013-07-12T02:50:47","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=567"},"modified":"2026-02-25T20:04:45","modified_gmt":"2026-02-25T20:04:45","slug":"comprehensive-molecular-diagnosis-of-179-leber-congenital-amaurosis-and-juvenile-retinitis-pigmentosa-patients-by-targeted-next-generation-sequencing","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2013\/07\/12\/comprehensive-molecular-diagnosis-of-179-leber-congenital-amaurosis-and-juvenile-retinitis-pigmentosa-patients-by-targeted-next-generation-sequencing\/","title":{"rendered":"Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing (Contributed by Xia Wang)"},"content":{"rendered":"

Leber congenital amaurosis (LCA) is the most severe retinal disease that causes blindness or severe visual impairment within the 1st<\/sup> year of life. Besides the 19 known LCA genes, the association between other known retinal disease genes and LCA has not been systematically studied. Here we report the largest cohort of LCA patients that is screened for mutations in all known LCA genes and most other known retinal disease genes. We demonstrate for the first time that homozygous mutations in PRPH2<\/i> cause LCA. We show that analyzing all possible genes leads to better insights in genotype-phenotype correlations. Our results highlight the importance of molecular diagnosis as an integral part of clinical diagnosis. (http:\/\/jmg.bmj.com\/content\/early\/2013\/07\/10\/jmedgenet-2013-101558<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Leber congenital amaurosis (LCA) is the most severe retinal disease that causes blindness or severe visual impairment within the 1st year of life. Besides the 19 known LCA genes, the association between other known retinal disease genes and LCA has not been systematically studied. Here we report the largest cohort of LCA patients that is […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-567","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nComprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing (Contributed by Xia Wang) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2013\/07\/12\/comprehensive-molecular-diagnosis-of-179-leber-congenital-amaurosis-and-juvenile-retinitis-pigmentosa-patients-by-targeted-next-generation-sequencing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing (Contributed by Xia Wang) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Leber congenital amaurosis (LCA) is the most severe retinal disease that causes blindness or severe visual impairment within the 1st year of life. 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