{"id":498,"date":"2013-03-06T19:34:22","date_gmt":"2013-03-06T19:34:22","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=498"},"modified":"2026-02-25T20:17:05","modified_gmt":"2026-02-25T20:17:05","slug":"recent-advances-in-the-molecular-genetics-of-epilepsy","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2013\/03\/06\/recent-advances-in-the-molecular-genetics-of-epilepsy\/","title":{"rendered":"Recent advances in the molecular genetics of epilepsy (Contributed by Drs. Sam Berkovic and Michael Hildebrand)"},"content":{"rendered":"

Remarkable advances in our understanding of epilepsies have occurred over the last 15 years. Concepts about etiology of epilepsies have been transformed from largely unknown to predominantly genetic through clinical genetic and molecular genetic advances. In this review we contrast the early breakthroughs in epilepsy genetics including the contribution of susceptibility alleles, de novo mutations and copy number variants using traditional genetic approaches with the rapid gene discovery now possible using new sequencing technologies. The successful rise of this latter technology provides the first real opportunity to unravel the complex genetic epilepsies and allow widespread clinical application of the discoveries. (http:\/\/jmg.bmj.com\/content\/early\/2013\/03\/05\/jmedgenet-2012-101448<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Remarkable advances in our understanding of epilepsies have occurred over the last 15 years. Concepts about etiology of epilepsies have been transformed from largely unknown to predominantly genetic through clinical genetic and molecular genetic advances. In this review we contrast the early breakthroughs in epilepsy genetics including the contribution of susceptibility alleles, de novo mutations […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-498","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nRecent advances in the molecular genetics of epilepsy (Contributed by Drs. Sam Berkovic and Michael Hildebrand) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2013\/03\/06\/recent-advances-in-the-molecular-genetics-of-epilepsy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recent advances in the molecular genetics of epilepsy (Contributed by Drs. 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In this review we contrast the early breakthroughs in epilepsy genetics including the contribution of susceptibility alleles, de novo mutations [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2013\/03\/06\/recent-advances-in-the-molecular-genetics-of-epilepsy\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2013-03-06T19:34:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T20:17:05+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/03\\\/06\\\/recent-advances-in-the-molecular-genetics-of-epilepsy\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/03\\\/06\\\/recent-advances-in-the-molecular-genetics-of-epilepsy\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Recent advances in the molecular genetics of epilepsy (Contributed by Drs. 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