{"id":470,"date":"2013-02-22T19:32:42","date_gmt":"2013-02-22T19:32:42","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=470"},"modified":"2026-02-25T20:17:25","modified_gmt":"2026-02-25T20:17:25","slug":"arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2013\/02\/22\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\/","title":{"rendered":"ARHGDIA: a novel gene implicated in nephrotic syndrome (Contributed by Dr. Indra Gupta)"},"content":{"rendered":"

Congenital nephrotic syndrome is a rare kidney disease in which affected infants lose protein in the urine and eventually develop kidney failure.\u00a0 Most cases are due to mutations in one of five genes.\u00a0 We have identified a mutation in a new gene, ARHGDIA,<\/i> encoding Rho GDP dissociation inhibitor alpha (RhoGDIa) that is responsible for this disorder in two sisters. RhoGDIa interacts with a family of proteins called the Rho-family of small GTPases that regulate the structure and motility of cells.\u00a0 Our data demonstrates that the mutation in ARHGDIA<\/i> disrupts the function of cells within the kidney that normally prevent the loss of protein.\u00a0 (http:\/\/jmg.bmj.com\/content\/early\/2013\/02\/21\/jmedgenet-2012-101442<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Congenital nephrotic syndrome is a rare kidney disease in which affected infants lose protein in the urine and eventually develop kidney failure.\u00a0 Most cases are due to mutations in one of five genes.\u00a0 We have identified a mutation in a new gene, ARHGDIA, encoding Rho GDP dissociation inhibitor alpha (RhoGDIa) that is responsible for this […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-470","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nARHGDIA: a novel gene implicated in nephrotic syndrome (Contributed by Dr. Indra Gupta) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2013\/02\/22\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ARHGDIA: a novel gene implicated in nephrotic syndrome (Contributed by Dr. Indra Gupta) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Congenital nephrotic syndrome is a rare kidney disease in which affected infants lose protein in the urine and eventually develop kidney failure.\u00a0 Most cases are due to mutations in one of five genes.\u00a0 We have identified a mutation in a new gene, ARHGDIA, encoding Rho GDP dissociation inhibitor alpha (RhoGDIa) that is responsible for this [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2013\/02\/22\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2013-02-22T19:32:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T20:17:25+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/02\\\/22\\\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/02\\\/22\\\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"ARHGDIA: a novel gene implicated in nephrotic syndrome (Contributed by Dr. Indra Gupta)\",\"datePublished\":\"2013-02-22T19:32:42+00:00\",\"dateModified\":\"2026-02-25T20:17:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/02\\\/22\\\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\\\/\"},\"wordCount\":124,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/02\\\/22\\\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/02\\\/22\\\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2013\\\/02\\\/22\\\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\\\/\",\"name\":\"ARHGDIA: a novel gene implicated in nephrotic syndrome (Contributed by Dr. Indra Gupta) - 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