{"id":346,"date":"2012-07-26T18:46:03","date_gmt":"2012-07-26T18:46:03","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=346"},"modified":"2026-02-25T20:34:49","modified_gmt":"2026-02-25T20:34:49","slug":"clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2012\/07\/26\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\/","title":{"rendered":"Clinical significance of copy number variations in the 11p15.5 imprinting control regions: new cases and review of the literature (Contributed by Prof. Thomas Eggermann)"},"content":{"rendered":"<p>The chromosomal region 11p15 harbours several imprinted genes, i.e. genes which are expressed in a parent-of-origin manner. Opposite molecular disturbances in 11p15 are associated with two distinct disorders associated with disturbed growth, Silver-Russell and Beckwith-Wiedemann syndrome. Due to the complexity of the 11p15 region and the interactions between the different genes, the interpretation of copy number variations in 11p15 \u00a0is complicated. The clinical outcome of micro-duplications or \u2013deletions is influenced by size, breakpoint positions and parental inheritance of the imbalance as well as by the imprinting status of the affected genes. Based on own cases and those from the literature we give an overview on the genotype-phenotype correlation in chromosomal rearrangements in 11p15 as the basis for a directed genetic counselling. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2012\/07\/25\/jmedgenet-2012-100967\">http:\/\/jmg.bmj.com\/content\/early\/2012\/07\/25\/jmedgenet-2012-100967<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The chromosomal region 11p15 harbours several imprinted genes, i.e. genes which are expressed in a parent-of-origin manner. Opposite molecular disturbances in 11p15 are associated with two distinct disorders associated with disturbed growth, Silver-Russell and Beckwith-Wiedemann syndrome. Due to the complexity of the 11p15 region and the interactions between the different genes, the interpretation of copy [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2012\/07\/26\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-346","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinical significance of copy number variations in the 11p15.5 imprinting control regions: new cases and review of the literature (Contributed by Prof. Thomas Eggermann) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2012\/07\/26\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical significance of copy number variations in the 11p15.5 imprinting control regions: new cases and review of the literature (Contributed by Prof. Thomas Eggermann) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"The chromosomal region 11p15 harbours several imprinted genes, i.e. genes which are expressed in a parent-of-origin manner. Opposite molecular disturbances in 11p15 are associated with two distinct disorders associated with disturbed growth, Silver-Russell and Beckwith-Wiedemann syndrome. Due to the complexity of the 11p15 region and the interactions between the different genes, the interpretation of copy [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2012\/07\/26\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2012-07-26T18:46:03+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T20:34:49+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/07\\\/26\\\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/07\\\/26\\\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Clinical significance of copy number variations in the 11p15.5 imprinting control regions: new cases and review of the literature (Contributed by Prof. Thomas Eggermann)\",\"datePublished\":\"2012-07-26T18:46:03+00:00\",\"dateModified\":\"2026-02-25T20:34:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/07\\\/26\\\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\\\/\"},\"wordCount\":154,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/07\\\/26\\\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/07\\\/26\\\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/07\\\/26\\\/clinical-significance-of-copy-number-variations-in-the-11p15-5-imprinting-control-regions-new-cases-and-review-of-the-literature\\\/\",\"name\":\"Clinical significance of copy number variations in the 11p15.5 imprinting control regions: new cases and review of the literature (Contributed by Prof. Thomas Eggermann) - 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