{"id":271,"date":"2012-03-05T19:59:13","date_gmt":"2012-03-05T19:59:13","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=271"},"modified":"2026-02-25T20:42:36","modified_gmt":"2026-02-25T20:42:36","slug":"the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2012\/03\/05\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\/","title":{"rendered":"The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain (Contributed by Paolo Peterlongo, IFOM)"},"content":{"rendered":"<p>We all have the same genes; however, DNA mutations within genes, inherited from parents and transmitted to children, together with environmental factors, make us all different. Some mutations increase the risk of developing diseases with respect to general population. Recently, the mutation rs12975333 has been \u201cassociated with increased breast cancer risk\u201d in the population of Antwerp, Belgium. We studied several thousands of persons from Germany, Italy, Australia and Spain and did not find anyone with the mutation. So, while rs12975333 may be responsible for breast cancer of some of the persons in Antwerp, it is absent in the other studied populations. (<a href=\"http:\/\/jmg.bmj.com\/content\/48\/10\/703\">http:\/\/jmg.bmj.com\/content\/48\/10\/703<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We all have the same genes; however, DNA mutations within genes, inherited from parents and transmitted to children, together with environmental factors, make us all different. Some mutations increase the risk of developing diseases with respect to general population. Recently, the mutation rs12975333 has been \u201cassociated with increased breast cancer risk\u201d in the population of [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2012\/03\/05\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-271","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain (Contributed by Paolo Peterlongo, IFOM) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2012\/03\/05\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain (Contributed by Paolo Peterlongo, IFOM) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"We all have the same genes; however, DNA mutations within genes, inherited from parents and transmitted to children, together with environmental factors, make us all different. Some mutations increase the risk of developing diseases with respect to general population. Recently, the mutation rs12975333 has been \u201cassociated with increased breast cancer risk\u201d in the population of [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2012\/03\/05\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2012-03-05T19:59:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T20:42:36+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/03\\\/05\\\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/03\\\/05\\\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain (Contributed by Paolo Peterlongo, IFOM)\",\"datePublished\":\"2012-03-05T19:59:13+00:00\",\"dateModified\":\"2026-02-25T20:42:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/03\\\/05\\\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\\\/\"},\"wordCount\":128,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/03\\\/05\\\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/03\\\/05\\\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2012\\\/03\\\/05\\\/the-rs12975333-variant-in-the-mir-125a-and-breast-cancer-risk-in-germany-italy-australia-and-spain\\\/\",\"name\":\"The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain (Contributed by Paolo Peterlongo, IFOM) - 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