{"id":2209,"date":"2026-07-26T15:40:51","date_gmt":"2026-07-26T15:40:51","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2209"},"modified":"2026-07-26T15:40:51","modified_gmt":"2026-07-26T15:40:51","slug":"field-watch-human-body-single-cell-atlas-of-three-dimensional-genome-organization-and-dna-methylation","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2026\/07\/26\/field-watch-human-body-single-cell-atlas-of-three-dimensional-genome-organization-and-dna-methylation\/","title":{"rendered":"Field watch: Human body single-cell atlas of three-dimensional genome organization and DNA methylation"},"content":{"rendered":"<p>A study published in Science presents a single-cell atlas of DNA methylation and three-dimensional genome organization across the human body. Zhou and colleagues profiled 86,689 nuclei from 16 adult tissues, characterizing 35 major cell types and 206 subtypes. Their findings reveal extensive cell type\u2013specific differences in methylation, chromatin loops, and long-range genome organization, while showing that these epigenomic features provide complementary information about cellular identity and differentiation. This resource may help researchers interpret how disease-associated genetic variants alter gene regulation in specific cell types. (<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adx0673\">https:\/\/www.science.org\/doi\/10.1126\/science.adx0673<\/a>)<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study published in Science presents a single-cell atlas of DNA methylation and three-dimensional genome organization across the human body. Zhou and colleagues profiled 86,689 nuclei from 16 adult tissues, characterizing 35 major cell types and 206 subtypes. Their findings reveal extensive cell type\u2013specific differences in methylation, chromatin loops, and long-range genome organization, while showing [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2026\/07\/26\/field-watch-human-body-single-cell-atlas-of-three-dimensional-genome-organization-and-dna-methylation\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2209","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Field watch: Human body single-cell atlas of three-dimensional genome organization and DNA methylation - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2026\/07\/26\/field-watch-human-body-single-cell-atlas-of-three-dimensional-genome-organization-and-dna-methylation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Field watch: Human body single-cell atlas of three-dimensional genome organization and DNA methylation - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"A study published in Science presents a single-cell atlas of DNA methylation and three-dimensional genome organization across the human body. Zhou and colleagues profiled 86,689 nuclei from 16 adult tissues, characterizing 35 major cell types and 206 subtypes. 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